NDLI: Different Cellular and Genetic Basis of Noise-Related Endocochlear Potential Reduction in CBA/J and BALB/cJ Mice

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The effect of static ear canal pressure on human spontaneous otoacoustic emissions: spectral width as a measure of the intra-cochlear oscillation amplitude.

Year: 2010 Volume: 11

Year: 2009 Volume: 10

Different Cellular and Genetic Basis of Noise-Related Endocochlear Potential Reduction in CBA/J and BALB/cJ Mice

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ohlemiller, Kevin K. Rosen, Allyson D. Rellinger, Erin A. Montgomery, Scott C. Gagnon, Patricia M.
Description	Country affiliation: United States Author Affiliation: Ohlemiller KK ( Department of Otolaryngology, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA. kohlemiller@wustl.edu)
Abstract	The acute and permanent effects of noise exposure on the endocochlear potential (EP) and cochlear lateral wall were evaluated in BALB/cJ (BALB) inbred mice, and compared with CBA/J (CBA) and C57BL/6 (B6) mice. Two-hour exposure to broadband noise (4–45 kHz) at 110 dB SPL leads to a ~50 mV reduction in the EP in BALB and CBA, but not B6. EP reduction in BALB and CBA is reliably associated with characteristic acute cellular pathology in stria vascularis and spiral ligament. By 8 weeks after exposure, the EP in CBA mice has returned to normal. In BALBs, however, the EP remains depressed by an average ~10 mV, so that permanent EP reduction contributes to permanent threshold shifts in these mice. We recently showed that the CBA noise phenotype in part reflects the influence of a large effect quantitative trait locus on Chr. 18, termed Nirep (Ohlemiller et al., Hear Res 260:47–53, 2010b). While CBA “EP susceptibility” alleles are dominant to those in B6, examination of (B6 × BALB) F1 hybrid mice and (F1 × BALB) N2 backcross mice revealed that noise-related EP reduction and associated cell pathology in BALBs are inherited in an autosomal recessive manner, and are dependent on multiple genes. Moreover, while N2 mice formed from B6 and CBA retain strong correspondence between acute EP reduction, ligament pathology, and strial pathology, N2s formed from B6 and BALB include subsets that dissociate pathology of ligament and stria. We conclude that the genes and cascades that govern the very similar EP susceptibility phenotypes in BALB and CBA mice need not be the same. BALBs appear to carry alleles that promote more pronounced long term effects of noise on the lateral wall. Separate loci in BALBs may preferentially impact stria versus ligament.
File Format	HTM / HTML
ISSN	15253961
e-ISSN	14387573
DOI	10.1007/s10162-010-0238-z
Journal	Journal of the Association for Research in Otolaryngology
Issue Number	1
Volume Number	12
Language	English
Publisher	Springer
Publisher Date	2011-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Otolaryngology Action Potentials Cochlea Physiopathology Hearing Loss, Noise-induced Genetics Animals Pathology Inheritance Patterns Mice Mice, Inbred Balb C Mice, Inbred Cba Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Sensory Systems

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Different Cellular and Genetic Basis of Noise-Related Endocochlear Potential Reduction in CBA/J and BALB/cJ Mice

Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea.

Divergent aging characteristics in CBA/J and CBA/CaJ mouse cochleae.

Reduction in sharpness of frequency tuning but not endocochlear potential in aging and noise-exposed BALB/cJ mice.

Long-term effects of acoustic trauma on electrically evoked otoacoustic emission.

Protection against noise-induced hearing loss in young CBA/J mice by low-dose kanamycin.

Temporal Coding by Cochlear Nucleus Bushy Cells in DBA/2J Mice with Early Onset Hearing Loss

Dynamics of noise-induced cellular injury and repair in the mouse cochlea.

A mouse model validates the utility of electrocochleography in verifying endolymphatic hydrops.

Different Cellular and Genetic Basis of Noise-Related Endocochlear Potential Reduction in CBA/J and BALB/cJ Mice

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Different Cellular and Genetic Basis of Noise-Related Endocochlear Potential Reduction in CBA/J and BALB/cJ Mice

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Different Cellular and Genetic Basis of Noise-Related Endocochlear Potential Reduction in CBA/J and BALB/cJ Mice