NDLI: Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Henkel, R. Fransman, W. Hipler, U-C Wiegand, C. Schreiber, G. Menkveld, R. Weitz, F. Fisher, D.
Description	Country affiliation: South Africa Author Affiliation: Henkel R ( Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa. rhenkel@uwc.ac.za)
Abstract	The biodiversity in South Africa provides more than 30,000 higher plants, of which more than 3000 are used by traditional healers to treat diseases. Typha capensis (bulrush) is one of the medicinal plants used in South Africa to treat male fertility problems. Considering that South African traditional healers have been recognised by Law and the health benefits of T. capensis have not been scientifically investigated yet, this study aimed at investigating the in vitro effects of aqueous extracts from this plant on male reproductive functions. Both leaves and rhizomes of T. capensis were dried, infused with distilled water and freeze-dried. Motile sperm from 50 men were isolated by swim-up and incubated with 1 µg ml(-1) aqueous extract of Typha rhizome for 1 h at 37 °C. Vitality, motility, sperm production of reactive oxygen species and mitochondrial membrane potential were analysed in the test sample, a control and in the pellet from the swim-up. Results showed that the rhizome extract had significant (P < 0.0001) negative effects on all parameters. The extracts from the leaves and rhizomes revealed dose-dependent inhibitory activity for collagenase and free radical formation. No inhibitory activity for elastase was found. The inhibitory activity for collagenase might indicate possible anti-cancer effects.
File Format	HTM / HTML
ISSN	03034569
Issue Number	Suppl 1
Volume Number	44
e-ISSN	14390272
Journal	Andrologia
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-05-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Urology Discipline Reproductive Medicine Enzyme Inhibitors Pharmacology Free Radical Scavengers Matrix Metalloproteinase Inhibitors Membrane Potentials Drug Effects Mitochondria Plant Extracts Sperm Motility Typhaceae Chemistry Humans Male Pilot Projects Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Urology Endocrinology

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