NDLI: Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study.

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Year: 2009 Volume: 35 Issue: 4

Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Woods, Scott W. Addington, Jean Cadenhead, Kristin S. Cannon, Tyrone D. Cornblatt, Barbara A. Heinssen, Robert Perkins, Diana O. Seidman, Larry J. Tsuang, Ming T. Walker, Elaine F. McGlashan, Thomas H.
Spatial Coverage	United States
Description	Country affiliation: United States Author Affiliation: Woods SW ( PRIME Prodromal Research Clinic, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA. scott.woods@yale.edu)
Abstract	Treatment and prevention studies over the past decade have enrolled patients believed to be at risk for future psychosis. These patients were considered at risk for psychosis by virtue of meeting research criteria derived from retrospective accounts of the psychosis prodrome. This study evaluated the diagnostic validity of the prospective 'prodromal risk syndrome' construct. Patients assessed by the Structured Interview for Prodromal Syndromes as meeting criteria of prodromal syndromes (n = 377) from the North American Prodrome Longitudinal Study were compared with normal comparison (NC, n = 196), help-seeking comparison (HSC, n = 198), familial high-risk (FHR, n = 40), and schizotypal personality disorder (SPD, n = 49) groups. Comparisons were made on variables from cross-sectional demographic, symptom, functional, comorbid diagnostic, and family history domains of assessment as well as on follow-up outcome. Prodromal risk syndrome patients as a group were robustly distinguished from NC subjects across all domains and distinguished from HSC subjects and from FHR subjects on most measures in many of these domains. Adolescent and young adult SPD patients, while distinct from prodromal patients on definitional grounds, were similar to prodromals on multiple measures, consistent with SPD in young patients possibly being an independent risk syndrome for psychosis. The strong evidence of diagnostic validity for the prodromal risk syndrome for first psychosis raises the question of its evaluation for inclusion in Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition).
File Format	HTM / HTML
ISSN	05867614
e-ISSN	17451701
DOI	10.1093/schbul/sbp027
Journal	Schizophrenia Bulletin
Issue Number	5
Volume Number	35
Language	English
Publisher	Oxford University Press
Publisher Date	2009-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Psychiatry Psychiatric Status Rating Scales Statistics & Numerical Data Psychotic Disorders Diagnosis Schizophrenia Schizophrenic Psychology Schizotypal Personality Disorder Adolescent Comorbidity Disability Evaluation Disease Progression Early Diagnosis Longitudinal Studies Patient Acceptance Of Health Care Psychology Psychometrics Genetics Reproducibility Of Results Risk Assessment Social Adjustment Multicenter Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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