NDLI: Basic symptoms and ultrahigh risk criteria: symptom development in the initial prodromal state.

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Basic symptoms and ultrahigh risk criteria: symptom development in the initial prodromal state.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schultze-Lutter, Frauke Ruhrmann, Stephan Berning, Julia Maier, Wolfgang Klosterkötter, Joachim
Spatial Coverage	Germany
Description	Country affiliation: Germany Author Affiliation: Schultze-Lutter F ( Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany. frauke.schultze-lutter@uk-koeln.de)
Abstract	Symptom development during the prodromal phase of psychosis was explored retrospectively in first-episode psychosis patients with special emphasis on the assumed time-related syndromic sequence of 'unspecific symptoms (UN)-predictive basic symptoms (BS)-attenuated psychotic symptoms (APS)-(transient) psychotic symptoms (PS).' Onset of syndromes was defined by first occurrence of any of their respective symptoms. Group means were inspected for time differences between syndromes and influence of sociodemographic and clinical characteristics on the recalled sequence. The sequence of 'UN-BS/APS-PS' was clearly supported, and both BS and, though slightly less, APS were highly sensitive. However, onset of BS and APS did not show significant time difference in the whole sample (N = 126; 90% schizophrenia), although when each symptom is considered independently, APS tended to occur later than first predictive BS. On descriptive level, about one-third each recalled an earlier, equal and later onset of BS compared with APS. Level of education showed the greatest impact on the recall of the hypothesized sequence. Thereby, those with a higher school-leaving certificate supported the assumed sequence, whereas those of low educational background retrospectively dated APS before BS. These findings rather point out recognition and recall bias inherent to the retrospective design than true group characteristics. Future long-term prospective studies will have to explore this conclusively. However, as regards the criteria, the results support the notion of BS as at least a complementary approach to the ultrahigh risk criteria, which may also allow for an earlier detection of psychosis.
File Format	HTM / HTML
ISSN	05867614
e-ISSN	17451701
DOI	10.1093/schbul/sbn072
Journal	Schizophrenia Bulletin
Issue Number	1
Volume Number	36
Language	English
Publisher	Oxford University Press
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Psychiatry Schizophrenia Diagnosis Schizophrenic Psychology Schizotypal Personality Disorder Adolescent Age Of Onset Early Diagnosis Genetic Predisposition To Disease Genetics Germany Psychiatric Status Rating Scales Retrospective Studies Psychology Sex Factors Multicenter Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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