NDLI: CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently.

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CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Klemann, C. Schade, J. Pabst, R. Leitner, S. Stiller, J. Von Hörsten, S. Stephan, M.
Description	Country affiliation: Germany Author Affiliation: Klemann C ( Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.)
Abstract	As CD26 (dipeptidyl peptidase 4/DPP4) rapidly truncates incretins N-terminally, including glucagon-like peptide-1, DPP4-inhibitors have been developed for treatment of diabetes type 2. To some extent this is surprising, as CD26/DPP4 is also deeply involved in immune regulation. Long-term pharmacological studies are hampered by off-target inhibition of DPP4-homologues. Therefore, we studied the effects of genetic CD26/DPP4-deficiency by investigating blood, spleen and thymus leucocyte subpopulations of wild-type and CD26-deficient F344-rats at different ages. In young animals at 1 and 3 months of age, there were no differences in leucocyte subsets, while in older animals the T cell composition was changed significantly. From the age of 6 months onwards, reduced numbers of recent thymic emigrants and memory T cells, and consequently an increased amount of naive T cells were observed in CD26-deficient rats. In addition, the architecture of the thymus was altered, as observed by a reduced density of lymphocytes in the medulla. Furthermore, the number of proliferating cells in the thymus was decreased in CD26-deficient rats at a higher age. Moreover, CD26-deficiency resulted in markedly reduced numbers of B cells in later life. Additionally, an age- but not CD26-dependent increase of regulatory T cells and a decrease of natural killer cell numbers were detected in the blood and spleen. Our findings indicate an important role of CD26 in maintaining lymphocyte composition, memory T cell generation and thymic emigration patterns during immunosenescence, with possible implications for using DPP4-inhibitors.
File Format	HTM / HTML
ISSN	00099104
e-ISSN	13652249
DOI	10.1111/j.1365-2249.2008.03839.x
Journal	Clinical & Experimental Immunology
Issue Number	2
Volume Number	155
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Immunology Aging Immunology Dipeptidyl Peptidase 4 Deficiency Lymphocyte Subsets Thymus Gland Pathology Animals Cd4-positive T-lymphocytes Cell Proliferation Genotype Granulocytes Immunologic Memory Killer Cells, Natural Leukocyte Count Rats, Inbred F344 T-lymphocyte Subsets T-lymphocytes, Regulatory Weight Gain Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently

Airway-specific recruitment of T cells is reduced in a CD26-deficient F344 rat substrain.

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Tracing thymic output in older individuals.

Thymic emigration: when and how T cells leave home

Post-thymic maturation: young T cells assert their individuality.

CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently.

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CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently.