NDLI: Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17ß-estradiol in embryonic zebrafish.

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Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17ß-estradiol in embryonic zebrafish.

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Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17ß-estradiol in embryonic zebrafish.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Saili, Katerine S. Tilton, Susan C. Waters, Katrina M. Tanguay, Robert L.
Description	Country affiliation: United States Author Affiliation: Saili KS ( Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, USA.)
Abstract	Transient developmental exposure to 0.1µM bisphenol A (BPA) results in larval zebrafish hyperactivity and learning impairments in the adult, while exposure to 80µM BPA results in teratogenic responses, including craniofacial abnormalities and edema. The mode of action underlying these effects is unclear. We used global gene expression analysis to identify candidate genes and signaling pathways that mediate BPA's developmental toxicity in zebrafish. Exposure concentrations were selected and anchored to the positive control, 17ß-estradiol (E2), based on previously determined behavioral or teratogenic phenotypes. Functional analysis of differentially expressed genes revealed distinct expression profiles at 24h post fertilization for 0.1µM versus 80µM BPA and 0.1µM versus 15µM E2 exposure, identification of prothrombin activation as a top canonical pathway impacted by both 0.1µM BPA and 0.1µM E2 exposure, and suppressed expression of several genes involved in nervous system development and function following 0.1µM BPA exposure.
File Format	HTM / HTML
ISSN	08906238
e-ISSN	18731708
DOI	10.1016/j.reprotox.2013.03.009
Journal	Reproductive Toxicology
Volume Number	38
Language	English
Publisher	Elsevier
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Embryology Discipline Reproductive Medicine Discipline Toxicology Benzhydryl Compounds Toxicity Embryo, Nonmammalian Drug Effects Estradiol Gene Expression Regulation, Developmental Phenols Teratogens Animals Metabolism Gene Expression Profiling Oligonucleotide Array Sequence Analysis Zebrafish Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Toxicology

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