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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Campion, Sarah N. Carvallo, Francisco R. Chapin, Robert E. Nowland, William S. Beauchamp, David Jamon, Raul Koitz, Rebecca Winton, Timothy R. Cappon, Gregg D. Hurtt, Mark E. |
| Description | Country affiliation: United States Author Affiliation: Campion SN ( Drug Safety Research and Development, Pfizer Worldwide Research & Development, Groton, CT, USA. sarah.campion@pfizer.com) |
| Abstract | Given the increasing use of Wistar Han (WH) rats in regulatory toxicology studies, these studies were performed to characterize the onset of sexual maturation in maturing WH rats as compared to Sprague-Dawley (SD) rats. Beginning on postnatal day (PND) 38 through PND 91 groups (n=8) of untreated WH rats were evaluated for maturation of the male reproductive system. Testicular spermatid head counts increased beginning on PND 42 until PND 70. Sperm were detected in the caput, corpus, and cauda epididymis on PND 45, 49, and 49, respectively, and counts increased through PND 91. Sperm motility was at adult levels by PND 63. The morphology of the testis/epididymis of all animals at day 70 or older was consistent with qualitative sexual maturity. Based on these endpoints, WH rats were determined to be sexually mature at PND 70, and many of these endpoints evaluated in SD rats exhibited nearly identical trends. |
| File Format | HTM / HTML |
| ISSN | 08906238 |
| Volume Number | 38 |
| e-ISSN | 18731708 |
| Journal | Reproductive Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Embryology Discipline Reproductive Medicine Discipline Toxicology Sexual Maturation Animals Epididymis Anatomy & Histology Male Organ Size Rats Rats, Sprague-dawley Rats, Wistar Sperm Count Testis Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Toxicology |
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