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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kristeller, Judith L. Zavorsky, Gerald S. Prior, John E. Keating, Doris A. Brady, Mary Ann Romaldini, Theresa A. Hickman, Tiera L. Stahl, Russell F. |
| Description | Country affiliation: United States Author Affiliation: Kristeller JL ( Department of Pharmacy Practice, School of Pharmacy, Wilkes University, Wilkes-Barre, Pennsylvania 18766, USA. Judith.kristeller@wilkes.edu) |
| Abstract | STUDY OBJECTIVE: Because alkalinization of the renal tubules can theoretically protect against the mechanisms of acute kidney injury, we sought to determine whether a sodium bicarbonate infusion can prevent acute kidney injury after cardiac surgery. DESIGN: Prospective, randomized, double-blind, controlled trial. SETTING: Cardiac surgery service in a community hospital. PATIENTS: Ninety-two patients with stage 3 or higher chronic kidney disease who underwent cardiac surgery using cardiopulmonary bypass. INTERVENTION: Forty-eight patients received a perioperative intravenous infusion of 0.9% sodium chloride 154 mEq/L, and 44 patients received an infusion of sodium bicarbonate infusion 150 mEq/L in 5% dextrose solution; the infusions were started 1 hour preoperatively and continued for 6 hours after cardiopulmonary bypass. MEASUREMENTS AND MAIN RESULTS: The primary outcome was the development of any stage of acute kidney injury within 5 days after surgery as defined by the Acute Kidney Injury Network criteria. No statistically significant difference in the primary outcome was noted between the two groups: 32% in the bicarbonate group versus 42% in the sodium chloride group (p=0.12). Likewise, no significant differences in the 30-day hospital mortality rate or other adverse outcomes were noted between the two groups. CONCLUSION: A perioperative infusion of sodium bicarbonate did not reduce the rate of acute kidney injury or adverse outcomes in patients with chronic kidney disease who underwent cardiac surgery. |
| File Format | HTM / HTML |
| ISSN | 02770008 |
| Issue Number | 7 |
| Volume Number | 33 |
| e-ISSN | 18759114 |
| Journal | Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Acute Kidney Injury Prevention & Control Cardiopulmonary Bypass Methods Postoperative Complications Sodium Bicarbonate Therapeutic Use Etiology Aged Aged, 80 And Over Cardiac Surgical Procedures Double-blind Method Female Hospital Mortality Hospitals, Community Humans Infusions, Intravenous Male Middle Aged Prospective Studies Administration & Dosage Treatment Outcome Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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