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Intravenous lidocaine for effective pain relief after a laparoscopic colectomy: a prospective, randomized, double-blind, placebo-controlled study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ahn, EunJin Kang, Hyun Choi, Geun Joo Park, Yong Hee Yang, So Young Kim, Beom Gyu Choi, Seung Won
Description	Country affiliation: South Korea Author Affiliation: Ahn E ( 1 Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.)
Abstract	A perioperative intravenous lidocaine infusion has been reported to decrease postoperative pain. The goal of this study was to evaluate the effectiveness of intravenous lidocaine in reducing postoperative pain for laparoscopic colectomy patients. Fifty-five patients scheduled for an elective laparoscopic colectomy were randomly assigned to 2 groups. Group L received an intravenous bolus injection of lidocaine 1.5 mg/kg before intubation, followed by 2 mg/kg/h continuous infusion during the operation. Group C received the same dosage of saline at the same time. Postoperative pain was assessed at 2, 4, 8, 12, 24, and 48 hours after surgery by using the visual analog scale (VAS). Fentanyl consumption by patient-controlled plus investigator-controlled rescue administration and the total number of button pushes were measured at 2, 4, 8, 12, 24, and 48 hours after surgery. In addition, C-reactive protein (CRP) levels were checked on the operation day and postoperative days 1, 2, 3, and 5. VAS scores were significantly lower in group L than group C until 24 hours after surgery. Fentanyl consumption was lower in group L than group C until 12 hours after surgery. Moreover, additional fentanyl injections and the total number of button pushes appeared to be lower in group L than group C (P < 0.05). The CRP level tended to be lower in group L than group C, especially on postoperative day 1 and 2 and appeared to be statistically significant. The satisfaction score was higher in group L than group C (P = 0.024). Intravenous lidocaine infusion during an operation reduces pain after a laparoscopic colectomy.
File Format	HTM / HTML
ISSN	00208868
e-ISSN	25202456
DOI	10.9738/INTSURG-D-14-00225.1
Journal	International Surgery
Issue Number	3
Volume Number	100
Language	English
Publisher	International College of Surgeons
Publisher Date	2015-03-01
Publisher Place	Italy
Access Restriction	Open
Subject Keyword	Discipline General Surgery Analgesics Therapeutic Use Colectomy Intraoperative Care Laparoscopy Lidocaine Pain, Postoperative Prevention & Control Preoperative Care Double-blind Method Infusions, Intravenous Injections, Intravenous Drug Therapy Prospective Studies Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Surgery

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