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Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhu, X. Sun, X. Wang, M. Zhang, C. Cao, Y. Mo, G. Liang, J. Zhu, S.
Description	Author Affiliation: Zhu X ( Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China. Electronic address: Metro1168@hotmail.com.); Sun X ( Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.); Wang M ( Department of Cardiac Surgery, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.); Zhang C ( Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.); Cao Y ( Department of Cardiac Surgery, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.); Mo G ( Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.); Liang J ( Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.); Zhu S ( Department of Cardiovascular Medicine, People's Hospital of Gaozhou, Gaozhou 525200, Guangdong, China.)
Abstract	BACKGROUND & AIMS: A growing body of evidence suggests that beta-glucan derived from oats or barley can reduce cardiovascular disease risk through reductions in serum lipids. However, the effects of beta-glucan on lipid changes in hypercholesterolemic patient groups are inconsistent. The objective of this study was to identify and quantify the effect of beta-glucan, a marker of water-soluble fiber, on various lipid parameters and glucose level in hypercholesterolemic subjects. METHODS AND RESULTS: We performed a comprehensive literature search to identify the relevant randomized controlled trials (RCTs) that investigated the effects of beta-glucan consumption in hypercholesterolemic subjects. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated for net changes in lipid concentrations by using fixed-effects or random-effects models according to heterogeneity. Publication bias, sensitivity analysis and subgroup analyses were also performed. Seventeen eligible RCTs with 916 subjects were included in the meta-analysis. The pooled result showed that beta-glucan consumption in hypercholesterolemic population significantly lowered the total cholesterol (TC) (MD, -0.26 mmol/L; 95% CI, -0.33 to -0.18; P < 0.00001) and low-density lipoprotein (LDL)-cholesterol concentration (MD, -0.21 mmol/L; 95% CI, -0.27 to -0.14; P < 0.00001). However, there were no significant differences in high-density lipoprotein (HDL)-cholesterol, triglycerides (TG) and glucose. No adverse effects were reported among the eligible trials. CONCLUSION: Our meta-analysis showed that beta-glucan consumption significantly decreased TC and LDL-cholesterol concentrations but did not affect TG, HDL-cholesterol, and glucose concentrations in hypercholesterolemic subjects.
File Format	HTM / HTML
ISSN	09394753
Issue Number	8
Volume Number	25
e-ISSN	15903729
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Language	English
Publisher	Elsevier
Publisher Date	2015-08-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Discipline Cardiology Discipline Vascular Diseases Discipline Nutritional Sciences Dietary Fiber Administration & Dosage Hypercholesterolemia Blood Diet Therapy Beta-glucans Therapeutic Use Avena Sativa Chemistry Blood Glucose Drug Effects Cholesterol Cholesterol, Ldl Female Hordeum Humans Lipoproteins, Hdl Male Treatment Outcome Triglycerides Journal Article Meta-analysis
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine

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