NDLI: Utility of genetic determinants of lipids and cardiovascular events in assessing risk.

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Utility of genetic determinants of lipids and cardiovascular events in assessing risk.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Holmes, Michael V. Harrison, Seamus Talmud, Philippa J. Hingorani, Aroon D. Humphries, Steve E.
Description	Country affiliation: United kingdom Author Affiliation: Holmes MV ( Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.)
Abstract	The prevention of coronary heart disease (CHD) is a major public-health goal, but disease architecture is such that a larger proportion of clinical events occur among the average majority than among the high-risk minority--the prevention paradox. Genetic findings over the past few years have resulted in the reopening of the old debate on whether an individualized or a population-based approach to prevention is preferable. Genetic testing is an attractive tool for CHD risk prediction because it is a low-cost, high-fidelity technology with multiplex capability. Moreover, by contrast with nongenetic markers, genotype is invariant and determined from conception, which eliminates biological variability and makes prediction from early life possible. Mindful of the prevention paradox, this Review examines the potential applications and challenges of using genetic information for predicting CHD, focusing on lipid risk factors and drawing on experience in the evaluation of nongenetic risk factors as screening tests for CHD. Many of the issues we discuss hold true for any late-onset common disease with modifiable risk factors and proven preventative strategies.
File Format	HTM / HTML
ISSN	17595002
Issue Number	4
Volume Number	8
e-ISSN	17595010
Journal	Nature Reviews Cardiology
Language	English
Publisher	Nature Publishing Group
Publisher Date	2011-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cardiology Coronary Artery Disease Prevention & Control Lipids Blood Risk Assessment Methods Diagnosis Genetics Ethnic Groups Genetic Testing Genetic Variation Genome, Human Genome-wide Association Study Humans Risk Factors Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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