NDLI: HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms.

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HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Navab, Mohamad Reddy, Srinivasa T. Van Lenten, Brian J. Fogelman, Alan M.
Description	Country affiliation: United States Author Affiliation: Navab M ( Department of Medicine, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095-1679, USA. mnavab@mednet.ucla.edu)
Abstract	The lipoprotein HDL has two important roles: first, it promotes reverse cholesterol transport, and second, it modulates inflammation. Epidemiological studies show that HDL-cholesterol levels are inversely correlated with the risk of cardiovascular events. However, many patients who experience a clinical event have normal, or even high, levels of HDL cholesterol. Measuring HDL-cholesterol levels provides information about the size of the HDL pool, but does not predict HDL composition or function. The main component of HDL, apolipoprotein A-I (apo A-I), is largely responsible for reverse cholesterol transport through the macrophage ATP-binding cassette transporter ABCA1. Apo A-I can be damaged by oxidative mechanisms, which render the protein less able to promote cholesterol efflux. HDL also contains a number of other proteins that are affected by the oxidative environment of the acute-phase response. Modification of the protein components of HDL can convert it from an anti-inflammatory to a proinflammatory particle. Small peptides that mimic some of the properties of apo A-I have been shown in preclinical models to improve HDL function and reduce atherosclerosis without altering HDL-cholesterol levels. Robust assays to evaluate the function of HDL are needed to supplement the measurement of HDL-cholesterol levels in the clinic.
File Format	HTM / HTML
ISSN	17595002
Issue Number	4
Volume Number	8
e-ISSN	17595010
Journal	Nature Reviews Cardiology
Language	English
Publisher	Nature Publishing Group
Publisher Date	2011-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cardiology Cardiovascular Diseases Pathology Cholesterol, Hdl Metabolism Cholesterol, Ldl Apolipoprotein A-i Physiology Humans Inflammation Oxidative Stress Risk Assessment Risk Factors Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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