NDLI: Facile and phase-defined determination of HLA alleles with morpholino-functionalized nanoparticle probes.

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Facile and phase-defined determination of HLA alleles with morpholino-functionalized nanoparticle probes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zu, Yanbing Tan, Min-Han Ren, Ee Chee Ying, Jackie Y.
Description	Country affiliation: Singapore Author Affiliation: Zu Y ( Institute of Bioengineering and Nanotechnology, Singapore, Singapore.); Tan MH ( Institute of Bioengineering and Nanotechnology, Singapore, Singapore.); Ren EC ( Singapore Immunology Network, 8A Biomedical Grove, Immunos, Singapore, Singapore.); Ying JY ( Institute of Bioengineering and Nanotechnology, Singapore, Singapore. Electronic address: jyying@ibn.a-star.edu.sg.)
Abstract	A number of human leukocyte antigen (HLA) gene alleles have been found to be genetic risk markers for immunologically mediated drug hypersensitivity. Clinical adoption of HLA pharmacogenomics requires facile and accurate allele screening assays. As HLA genes are highly polymorphic, currently available methods are usually labor-intensive and liable to generate false positives. Herein we report a general strategy for screening HLA alleles with nanoparticle probes. Specific HLA alleles can be identified by gauging three to five sequence variants. Single-polymerase chain reaction (PCR) and dual-PCR methods have been proposed to achieve phase-defined determination of the sequence variants. Morpholino-functionalized gold nanoparticle probes allow for colorimetric and highly specific detection. Assays for HLA-B58:01 and HLA-B15:02 have been developed and validated with 49 selected human genomic DNA samples. The facile nanoparticle probe-based assays can be implemented easily in molecular diagnostic laboratories for accurate and cost-effective screening of HLA alleles.
File Format	HTM / HTML
ISSN	15499634
Journal	Nanomedicine: Nanotechnology, Biology and Medicine
e-ISSN	15499642
Language	English
Publisher	Elsevier
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nanotechnology Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Molecular Medicine Bioengineering Biomedical Engineering Pharmaceutical Science

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