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Control of innate and adaptive immunity by the inflammasome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ciraci, Ceren Janczy, John R. Sutterwala, Fayyaz S. Cassel, Suzanne L.
Description	Country affiliation: United States Author Affiliation: Ciraci C ( Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.)
Abstract	The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.
File Format	HTM / HTML
ISSN	12864579
e-ISSN	1769714X
DOI	10.1016/j.micinf.2012.07.007
Journal	Microbes and Infection
Issue Number	14
Volume Number	14
Language	English
Publisher	Elsevier
Publisher Date	2012-11-01
Publisher Place	France
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Immunology Adaptive Immunity Physiology Immunity, Innate Inflammasomes Immunology Animals Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology Microbiology

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