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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | García-Lestón, Julia Roma-Torres, Joana Mayan, Olga Schroecksnadel, Sebastian Fuchs, Dietmar Moreira, Ana O. Pásaro, Eduardo Méndez, Josefina Teixeira, João Paulo Laffon, Blanca |
| Spatial Coverage | Portugal Spain |
| Description | Country affiliation: Spain Author Affiliation: García-Lestón J ( Toxicology Unit, Department of Psychobiology, University of A Coruña, A Coruña, Spain. jgarciale@udc.es) |
| Abstract | Although adverse health effects produced by lead (Pb) have long been recognized, studies regarding the immunotoxic effects of occupational exposure report conflicting results. In a previous study, alterations in some immunological parameters were noted in 70 Pb-exposed workers. In view of these results, it was of interest to extend this study comprising a larger population and increasing the number of immunological endpoints assessed. Accordingly, in this study the immunotoxic effects of occupational exposure to Pb were assessed by analyzing (1) percentages of lymphocyte subsets (CD3âº, CD4âº, CD8âº, CD19âº, and CD56âº/16âº); (2) concentration of plasma cytokines, namely, interleukin (IL) 2, IL4, IL6, IL10, tumor necrosis factor (TNF) , and interferon (IFN) γ; and (3) plasma concentrations of neopterin, tryptophan (Trp), and kynurenine (Kyn). In addition, the possible influence of genetic polymorphisms in the vitamin D receptor (VDR) and δ-aminolevulinic acid dehydratase (ALAD) genes on immunotoxicity parameters was studied. Exposed workers showed significant decreases in %CD3âº, %CD4âº/%CD8⺠ratio, IL4, TNF , IFNγ, and Kyn to Trp ratio (Kyn/Trp), and significant increases in %CD8âº, IL10, and Trp levels. All these parameters, except Trp, were significantly correlated with exposure biomarkers. No significant influence of genetic polymorphisms was observed. Significant correlation between Kyn/Trp and neopterin concentrations suggests an involvement of indoleamine 2,3-dioxygenase in the Trp metabolic alterations, which may contribute to some of the immune alterations observed. Results obtained suggest that occupational exposure to PB may influence the immune system by impairing several mechanisms, which might ultimately produce deregulation of the immune response and diminish immunosurveillance in exposed individuals. |
| File Format | HTM / HTML |
| ISSN | 15287394 |
| Issue Number | 13-15 |
| Volume Number | 75 |
| e-ISSN | 10872620 |
| Journal | Journal of Toxicology and Environmental Health, Part A |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Toxicology Immunosuppressive Agents Toxicity Lead Poisoning Immunology Lead Occupational Exposure Adult Biological Markers Blood Cytokines Genetic Association Studies Humans Industry Kynurenine Enzymology Genetics Lymphocyte Subsets Drug Effects Male Middle Aged Neopterin Polymorphism, Genetic Porphobilinogen Synthase Portugal Receptors, Calcitriol Smoking Spain Tryptophan Journal Article Multicenter Study Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Toxicology |
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