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Effect of lead on the levels of some immunoregulatory cytokines in occupationally exposed workers
| Content Provider | SAGE Publishing |
|---|---|
| Author | Valentino, M. Rapisarda, V. Santarelli, L. Bracci, M. Scorcelletti, M. Lorenzo, L. Di Cassano, F. Soleo, L. |
| Abstract | Lead (Pb) may affect humoral and cellular immunity, acting on lymphocytes as well as on granulocytes and monocytes. Cytokines and nitric oxide (NO) play a central role in the immune balance. In this study, plasma levels of nitrites and nitrates (NOx), IL2, IL4, IL6, IL10, TNF-α and INF-γ, were measured in healthy workers with very low (Pb-B =3.2 -18.0 μg/dL) and low (Pb-B = 9.1 -46.0 μg/dL) Pb-exposure compared to non-exposed workers. Low Pb-exposed workers (Pb-B =9.1 -46.0 μg/ dL) were found to have significantly higher plasma IL-10 levels, and tendentially higher plasma TNF-α levels compared to non-exposed workers. This is the first report of a significant increase of plasma IL-10 levels in Pb-exposed workers. Plasma IL-10 increase was influenced by blood Pb levels even after correction for main confounding factors. No difference was found in plasma NOx levels between Pb-exposed and non-exposed workers, which is in agreement with previous findings exclusively regarding groups in the general population. Low Pb-exposure can induce an increase of pro-inflammatory cytokines, such as TNF-α, with a consequent increase of other cytokines, such as IL-10, considered a T cell cross-regulatory factor, suggesting possible interference of Pb in the system of immunophlogosis. Human & Experimental Toxicology (2007) 26, 551 - 556 |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/0960327107073817?download=true |
| Starting Page | 551 |
| Ending Page | 556 |
| Page Count | 6 |
| ISSN | 09603271 |
| Issue Number | 7 |
| Volume Number | 26 |
| Journal | Human & Experimental Toxicology (HET) |
| e-ISSN | 14770903 |
| DOI | 10.1177/0960327107073817 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2007-07-01 |
| Publisher Place | London |
| Access Restriction | Open |
| Subject Keyword | cytokine NOx lead occupational exposure IL 10 TNF-α |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology |
