| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Rosa, Josiane de Lima Cavariani, Marilia Martins Borges, Cibele dos Santos Leite, Gabriel Adan Araújo Anselmo-Franci, Janete Aparecida Kempinas, Wilma De Grava |
| Description |
Country affiliation: Brazil Author Affiliation: Rosa Jde L ( a Laboratory of Biology and Toxicology of Reproduction and Development, Department of Morphology , Institute of Biosciences, UNESP-Universidade Estadual Paulista , Botucatu , São Paulo , Brazil.); Cavariani MM ( a Laboratory of Biology and Toxicology of Reproduction and Development, Department of Morphology , Institute of Biosciences, UNESP-Universidade Estadual Paulista , Botucatu , São Paulo , Brazil.); Borges Cdos S ( a Laboratory of Biology and Toxicology of Reproduction and Development, Department of Morphology , Institute of Biosciences, UNESP-Universidade Estadual Paulista , Botucatu , São Paulo , Brazil.); Leite GA ( a Laboratory of Biology and Toxicology of Reproduction and Development, Department of Morphology , Institute of Biosciences, UNESP-Universidade Estadual Paulista , Botucatu , São Paulo , Brazil.); Anselmo-Franci JA ( b Department of Morphology, Stomatology and Physiology, School of Dentistry , USP-Universidade de São Paulo , Ribeirão Preto , São Paulo , Brazil.); Kempinas Wde G ( a Laboratory of Biology and Toxicology of Reproduction and Development, Department of Morphology , Institute of Biosciences, UNESP-Universidade Estadual Paulista , Botucatu , São Paulo , Brazil.) |
| Abstract |
Interferon-alpha (IFN- ), a type I IFN, is a protein with antiviral, antiproliferative, and immunoregulatory activities, widely used in the treatment of several types of cancers as well as hepatitis B and C. Decrease of libido and erectile dysfunction are commonly reported by male patients during treatment of chronic hepatitis C with IFN- . However, IFN therapy-associated underlying factors attributed to sexual dysfunction are still not well defined. Currently, there are few studies investigating the effects of IFN on male reproductive system functions. Given that, the aim of the present investigation was to examine effects of subchronic exposure to IFN- (5 × 10(4) U/kg and 10 × 10(4) U/kg, 30 d) on serum hormones, sperm parameters, fertility, and testicular and epididymal hystopathology and morphometry in adult male Wistar rats. None of the evaluated parameters was markedly altered by IFN- . Thus, our results suggest that exposure to IFN- , in this experimental design, did not adversely affect sperm quality and fertile capacity of male rats. |
| File Format |
HTM / HTML |
| ISSN |
15287394 |
| Issue Number |
20 |
| Volume Number |
78 |
| e-ISSN |
10872620 |
| Journal |
Journal of Toxicology and Environmental Health, Part A |
| Language |
English |
| Publisher |
Taylor & Francis |
| Publisher Date |
2015-01-01 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Environmental Health Discipline Toxicology Antiviral Agents Toxicity Interferon-alpha Reproduction Drug Effects Animals Administration & Dosage Dose-response Relationship, Drug Epididymis Anatomy & Histology Fertility Hormones Blood Male Random Allocation Rats Rats, Wistar Spermatozoa Physiology Testis Toxicity Tests, Subchronic Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Health, Toxicology and Mutagenesis Toxicology |
