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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | César, Isabela Costa Bastos, Leandro Francisco Silva Godin, Adriana Martins Coelho, Márcio de Matos Araujo, Débora Pereira de Fátima, Ângelo Guidine, Patrícia Alves Maia Pianetti, Gerson Antônio |
| Description | Country affiliation: Brazil Author Affiliation: César IC ( Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos 6627, 31270-901, Belo Horizonte, MG, Brazil. isaccesar@bol.com.br) |
| Abstract | A liquid chromatography-electrospray ionization tandem mass spectrometry method was developed and validated for the simultaneous quantitation of nicorandil and its denitrated metabolite, N-(2-hydroxyethyl)-nicotinamide, in rat plasma. After a liquid-liquid extraction step, chromatographic separation was performed on a ShinPack C(18) column with an isocratic mobile phase composed of methanol and 2 mM aqueous ammonium acetate containing 0.03% (v/v) formic acid (33:67 v/v). Procainamide was used as an internal standard (IS). Selected reaction monitoring was performed using the transitions m/z 212 â m/z 135, m/z 166 â m/z 106 and m/z 236 â m/z 163 to quantify nicorandil, its denitrated metabolite and IS, respectively. Calibration curves were constructed over the range of 5-15,000 ng.ml(-1) for both nicorandil and its metabolite. The mean relative standard deviation (RSD%) values for the intra-run precision were 5.4% and 7.3% and for the inter-run precision were 8.5% and 7.3% for nicorandil and its metabolite, respectively. The mean accuracy values were 100% and 95% for nicorandil and its metabolite, respectively. No matrix effect was detected in the samples. The validated method was successfully applied to a pharmacokinetic study after per os administration of nicorandil in rats. |
| File Format | HTM / HTML |
| ISSN | 10765174 |
| Issue Number | 11 |
| Volume Number | 46 |
| e-ISSN | 10969888 |
| Journal | Journal of Mass Spectrometry |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2011-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Spectroscopy Discipline Chemistry Techniques Chromatography, Liquid Methods Niacinamide Analogs & Derivatives Nicorandil Blood Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Animals Female Male Pharmacokinetics Procainamide Rats Rats, Wistar Reproducibility Of Results Sensitivity And Specificity Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Medicine |
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