NDLI: N-alkylpyridinium quaternization for assisting electrospray ionization of sterols in oil by quadrupole-time of flight mass spectrometry.

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N-alkylpyridinium quaternization for assisting electrospray ionization of sterols in oil by quadrupole-time of flight mass spectrometry.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Hang Wang, Haoyang Zhang, Li Zhang, Jing Leng, Jiapeng Cai, Tingting Guo, Yinlong
Description	Country affiliation: China Author Affiliation: Wang H ( Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Lingling Road 345, 200032, Shanghai, China)
Abstract	RATIONALE: The illegal cooking oil has become a serious social problem and raised widespread alarm recently. However, an efficient and sensitive technique for identifying the potential illegal cooking oil is still unavailable, especially when mixed with the ordinary ones; there is an urgent need to develop an efficient method for identifying the illegal cooking oil. Sterols in the cooking oil could be used as an indicator to identify the source and quality of oil by detecting the kinds of phytosterols and zoosterols. However, those sterols are difficult to be ionized by electrospray ionization, which resulted in the low sensitivity in electrospray ionization (ESI)-mass spectrometric (MS) analysis. METHODS: N-alkylpyridinium isotope quaternization was extended to charge label sterols in different cooking oil and attached N-cationic pyridinium tag onto the sterols in the presence of trifluoromethanesulfonic anhydride (Tf2 O); the kinds of sterols were identified and quantified by comparing d0 /d5 pairs and product scan from ESI-quadrupole-time of flight (Q-TOF) MS analysis. RESULTS: The derivatized sterols were attached with permanent charge, resulting in the significant enhancement of ionization in ESI-Q-TOF MS analysis. The detection limits of analytes were improved to 0.02-0.05 ng/mL; different kinds of phytosterol, zoosterol and oxides were identified and quantified by comparing d0 /d5 pairs from full scan and product scan. The method was applied in the detection of zoosterol for identifying the potential recycled cooking oil, even when the illegal oil has been blended into the ordinary one. More zoosterol was detected in the recycled oil compared with other cooking oil. CONCLUSIONS: The use of N-alkylpyridinium isotope quaternization method provided an alternative method for identifying the potential illegal cooking oil.
File Format	HTM / HTML
ISSN	10765174
Issue Number	10
Volume Number	48
e-ISSN	10969888
Journal	Journal of Mass Spectrometry
Language	English
Publisher	Wiley
Publisher Date	2013-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Spectroscopy Discipline Chemistry Techniques Dietary Fats, Unsaturated Analysis Food Analysis Methods Spectrometry, Mass, Electrospray Ionization Sterols Limit Of Detection Evaluation Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Medicine

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