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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Theis, Jason D. Dasari, Surendra Vrana, Julie A. Kurtin, Paul J. Dogan, Ahmet |
| Description | Country affiliation: United States Author Affiliation: Theis JD ( Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.) |
| Abstract | Shotgun proteomics technology has matured in the research laboratories and is poised to enter clinical laboratories. However, the road to this transition is sprinkled with major technical unknowns such as long-term stability of the platform, reproducibility of the technology and clinical utility over traditional antibody-based platforms. Further, regulatory bodies that oversee the clinical laboratory operations are unfamiliar with this new technology. As a result, diagnostic laboratories have avoided using shotgun proteomics for routine diagnostics. In this perspectives article, we describe the clinical implementation of a shotgun proteomics assay for amyloid subtyping, with a special emphasis on standardizing the platform for better quality control and earning clinical acceptance. This assay is the first shotgun proteomics assay to receive regulatory approval for patient diagnosis. The blueprint of this assay can be utilized to develop novel proteomics assays for detecting numerous other disease pathologies. |
| File Format | HTM / HTML |
| ISSN | 10765174 |
| Issue Number | 10 |
| Volume Number | 48 |
| e-ISSN | 10969888 |
| Journal | Journal of Mass Spectrometry |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Spectroscopy Discipline Chemistry Techniques Amyloid Analysis Amyloidosis Diagnosis Proteomics Methods Tandem Mass Spectrometry Classification Humans Reproducibility Of Results Journal Article Research Support, Non-u.s. Gov't Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Medicine |
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