NDLI: Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line.

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Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bastos, Verónica Ferreira-de-Oliveira, José M. P. Carrola, Joana Daniel-da-Silva, Ana L. Duarte, Iola F. Santos, Conceição Oliveira, Helena
Description	Author Affiliation: Bastos V ( CESAM & Laboratory of Biotechnology and Cytomics, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: veronicabastos@ua.pt.); Ferreira-de-Oliveira JM ( CESAM & Laboratory of Biotechnology and Cytomics, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.); Carrola J ( CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.); Daniel-da-Silva AL ( CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.); Duarte IF ( CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.); Santos C ( Department of Biology, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal. Electronic address: csantos@fc.up.pt.); Oliveira H ( CESAM & Laboratory of Biotechnology and Cytomics, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.)
Abstract	The antibacterial potential of silver nanoparticles (AgNPs) resulted in their increasing incorporation into consumer, industrial and biomedical products. Therefore, human and environmental exposure to AgNPs (either as an engineered product or a contaminant) supports the emergent research on the features conferring them different toxicity profiles. In this study, 30 nm AgNPs coated with citrate or poly(ethylene glycol) (PEG) were used to assess the influence of coating on the effects produced on a human hepatoma cell line (HepG2), namely in terms of viability, apoptosis, apoptotic related genes, cell cycle and cyclins gene expression. Both types of coated AgNPs decreased cell proliferation and viability with a similar toxicity profile. At the concentrations used (11 and 5 μg/mL corresponding to IC50 and ~ IC10 levels, respectively) the amount of cells undergoing apoptosis was not significant and the apoptotic related genes BCL2 (anti-apoptotic gene) and BAX (pro-apoptotic gene) were both downregulated. Moreover, both AgNPs affected HepG2 cell cycle progression at the higher concentration (11 μg/mL) by increasing the percentage of cells in S (synthesis phase) and G2 (Gap 2 phase) phases. Considering the cell-cycle related genes, the expression of cyclin B1 and cyclin E1 genes were decreased. Thus, this work has shown that citrate- and PEG-coated AgNPs impact on HepG2 apoptotic gene expression, cell cycle dynamics and cyclin regulation in a similar way. More research is needed to determine the properties that confer AgNPs at lower toxicity, since their use has proved helpful in several industrial and biomedical contexts.
File Format	HTM / HTML
ISSN	10010742
Volume Number	51
Journal	Journal of Environmental Sciences
Language	English
Publisher	Elsevier
Publisher Date	2017-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Anti-bacterial Agents Toxicity Citric Acid Hazardous Substances Metal Nanoparticles Polyethylene Glycols Silver Carcinoma, Hepatocellular Cell Line, Tumor Humans Liver Neoplasms Journal Article
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Medicine Environmental Engineering

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