NDLI: Mechanisms of ligand specificity of the mineralocorticoid receptor.

Please wait, while we are loading the content...

Prolactin177, prolactin188 and prolactin receptor 2 in the pituitary of the euryhaline tilapia, Oreochromis mossambicus, are differentially osmosensitive.

Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta.

Unchanged interleukin 6 level of protein and energy restricted goats during late gestation: the role of elevated blood nitric oxide.

Testosterone modulates platelet aggregation and endothelial cell growth through nitric oxide pathway.

Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation.

Molecular and functional characterization of cionin receptors in the ascidian, Ciona intestinalis: the evolutionary origin of the vertebrate cholecystokinin/gastrin family.

Year: 2012 Volume: 212

Year: 2011 Volume: 211

Year: 2011 Volume: 210

Year: 2011 Volume: 209

Year: 2011 Volume: 208

Year: 2010 Volume: 207

Year: 2010 Volume: 206

Year: 2010 Volume: 205

Year: 2010 Volume: 204

Year: 2009 Volume: 203

Year: 2009 Volume: 202

Year: 2009 Volume: 201

Year: 2009 Volume: 200

Year: 2008 Volume: 199

Year: 2008 Volume: 198

Year: 2008 Volume: 197

Year: 2008 Volume: 196

Year: 2007 Volume: 195

Year: 2007 Volume: 194

Year: 2007 Volume: 193

Year: 2007 Volume: 192

Year: 2006 Volume: 191

Year: 2006 Volume: 190

Year: 2006 Volume: 189

Year: 2005 Volume: 185

Year: 2005 Volume: 184

Year: 2004 Volume: 183

Year: 2004 Volume: 181

Year: 1999 Volume: 160

Year: 1998 Volume: 159

Mechanisms of ligand specificity of the mineralocorticoid receptor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fuller, Peter J. Yao, Yizou Yang, Jun Young, Morag J.
Description	Country affiliation: Australia Author Affiliation: Fuller PJ ( Prince Henry's Institute and the Monash University, Department of Medicine, Clayton, Victoria 3168, Australia. peter.fuller@princehenrys.org)
Abstract	The mineralocorticoid receptor (MR) differs from the other steroid receptors in that it responds to two physiological ligands, aldosterone and cortisol. In epithelial tissues, aldosterone selectivity is determined by the activity of 11ß-hydroxysteroid dehydrogenase type 2, while in other tissues, including the heart and regions of the central nervous system, cortisol is the primary ligand for the MR where it may act as an antagonist. Clinical trials have demonstrated the potential of MR antagonists in the treatment of cardiovascular disease, though their use has been limited by concurrent hyperkalaemia. In order to better target the MR, an understanding of the structural determinants of tissue- and ligand-specific MR activation is needed. Interactions of the MR have been identified, which exhibit ligand discrimination and/or specificity. These interactions include those of the ligand-binding domain with ligand, with the N-terminal domain and with putative co-regulatory molecules. Agonist and antagonist binding have been characterised using chimeras between the human MR and the glucocorticoid receptor or the zebra fish MR together with molecular modelling. The interaction between the N-terminus and the C-terminus is aldosterone dependent but is unexpectedly antagonised by cortisol and deoxycorticosterone in the human MR. Nuclear receptor-mediated transactivation is critically dependent on, and modulated by, co-regulatory molecules. Proteins that interact with the MR in the presence of either aldosterone or cortisol, but not both, have been identified. The successful identification of ligand-specific interactions of the MR may provide the basis for the development of novel MR ligands with tissue specificity.
File Format	HTM / HTML
ISSN	00220795
e-ISSN	14796805
Journal	Journal of Endocrinology
Issue Number	1
Volume Number	213
Language	English
Publisher	BioScientifica
Publisher Date	2012-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Endocrinology Aldosterone Chemistry Hydrocortisone Receptors, Mineralocorticoid Metabolism Animals Ligands Mineralocorticoid Receptor Antagonists Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Endocrinology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Aldosterone and inflammation.

Mineralocorticoid receptors in the heart: lessons from cell-selective transgenic animals.

Cardiac corticosteroid receptors mediate the enlargement of the ovine fetal heart induced by chronic increases in maternal cortisol.

Mineralocorticoid Receptor Antagonists and Clinical Outcomes in Primary Aldosteronism: As Good as Surgery?

Implication of the mineralocorticoid axis in rainbow trout osmoregulation during salinity acclimation.

Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis

Mineralocorticoid receptors in the brain and cardiovascular regulation: minority rule?

Identification of mineralocorticoid target sites in the isolated rabbit cortical nephron.

Evolving research in nongenomic actions of aldosterone.

Mechanisms of ligand specificity of the mineralocorticoid receptor.

Similar Documents

Aldosterone and inflammation.

Mineralocorticoid receptors in the heart: lessons from cell-selective transgenic animals.

Cardiac corticosteroid receptors mediate the enlargement of the ovine fetal heart induced by chronic increases in maternal cortisol.

Mineralocorticoid Receptor Antagonists and Clinical Outcomes in Primary Aldosteronism: As Good as Surgery?

Implication of the mineralocorticoid axis in rainbow trout osmoregulation during salinity acclimation.

Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis

Mineralocorticoid receptors in the brain and cardiovascular regulation: minority rule?

Identification of mineralocorticoid target sites in the isolated rabbit cortical nephron.

Evolving research in nongenomic actions of aldosterone.

Mechanisms of ligand specificity of the mineralocorticoid receptor.