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Fracture risk in early postmenopausal women assessed using FRAX.

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Fracture risk in early postmenopausal women assessed using FRAX.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Trémollieres, Florence Cochet, Tiffany Cohade, Clémentine Pouillès, Jean-Michel Ribot, Claude
Spatial Coverage	France
Description	Country affiliation: France Author Affiliation: Trémollieres F ( Centre de ménopause, hôpital Paule-de-Viguier, 330, avenue de Grande-Bretagne, TSA 70034, 31059 Toulouse cedex 9, France. tremollieres.f@chu-toulouse.fr)
Abstract	OBJECTIVES: To evaluate FRAX 10-year fracture probabilities depending on the recommended management strategy in early postmenopausal women who were untreated at baseline. METHODS: We conducted a descriptive study in 494 untreated women aged 45-60 years seen for the first time at a menopause clinic. Risk factors, physical findings, and bone mineral density (BMD) values determined by dual-energy X-ray absorptiometry were collected. At the end of the clinic visit, 128 (26%) women were prescribed medications. Then, the 10-year fracture probability was estimated using the FRAX tool. RESULTS: The mean FRAX probability was 3.9%+/-2% for major osteoporotic fractures and 0.8%+/-0.9% for hip fractures. Women who were prescribed medications had significantly (P<0.001) higher probabilities than the other women. The proportion of women prescribed medications increased significantly (P<0.0001) with the FRAX probability, from 7.8% in the lowest quintile (Q1) to 50.5% in Q5. Hormone replacement therapy or raloxifene contributed 92% of the prescriptions in patients with FRAX probabilities in the first four quintiles and bisphosphonates 70% of prescriptions in patients with probabilities in Q5. CONCLUSIONS: Early postmenopausal women had low to moderate fracture risks (FRAX, 3-4%). The indications and type of drugs prescribed correlated with FRAX probabilities. Treatment thresholds should be defined to optimize the management of osteoporosis. In early postmenopausal women, treatment thresholds may vary with the type of treatment.
File Format	HTM / HTML
ISSN	1297319X
Issue Number	4
Volume Number	77
e-ISSN	17787254
Journal	Joint Bone Spine
Language	English
Publisher	Elsevier
Publisher Date	2010-07-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Rheumatology Fractures, Bone Epidemiology Models, Statistical Osteoporosis, Postmenopausal Complications Absorptiometry, Photon Bone Density Bone Density Conservation Agents Therapeutic Use Diphosphonates Estrogen Replacement Therapy Female France Hip Fractures Humans Middle Aged Diagnosis Drug Therapy Raloxifene Risk Factors Evaluation Studies Journal Article
Content Type	Text
Resource Type	Article
Subject	Rheumatology

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