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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Caramaschi, Paola Poli, Giovanni Bonora, Adriana Volpe, Alessandro Tinazzi, Ilaria Pieropan, Sara Bambara, Lisa M. Biasi, Domenico |
| Spatial Coverage | Italy |
| Description | Country affiliation: Italy Author Affiliation: Caramaschi P ( Dipartimento di Medicina Clinica Sperimentale, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. paola.caramaschi@azosp.vr.it) |
| Abstract | BACKGROUND: Behcet's disease (BD) may complicate with arterial and venous thrombosis. The purpose of this work is to evaluate in an Italian group of BD patients with thrombotic events a large panel of inherited and acquired thrombophilic factors. METHODS: Thirty BD patients, of which nine with previously arterial or venous thrombosis and 21 without, underwent the following investigations: plasma antithrombin activity, protein C activity, free protein S level, sensitivity to APC, total plasma homocysteine concentration, serum folate level, determination of anti-phospholipid antibodies, serum Lp(a) levels, tests for gene polymorphisms of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase genes. Tests for the gene polymorphisms were also performed in a group of healthy control subjects. RESULTS: All the six patients with arterial or deep venous thrombosis showed thrombophilic conditions such as protein C or protein S deficiency (one case each), hyperhomocysteinemia (two cases), positivity of anti-phospholipid antibodies associated with APC resistance or hyperhomocysteinemia (one case each). Among three subjects with superficial thrombophlebitis only one showed a mild hyperhomocysteinemia. No differences were found between BD patients and control subjects concerning polymorphisms of the genes considered. Among BD patients the Factor V H1299R mutation showed a weak association with venous thrombosis (P=0.048). CONCLUSION: In BD patients different concomitant significant thrombophilic risk factors may contribute to the development of thrombotic events. Patients affected by vasculo-Behcet should be evaluated for the presence of coexisting major thrombophilic conditions. |
| File Format | HTM / HTML |
| ISSN | 1297319X |
| Issue Number | 4 |
| Volume Number | 77 |
| e-ISSN | 17787254 |
| Journal | Joint Bone Spine |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-07-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Rheumatology Behcet Syndrome Blood Complications Thrombosis Etiology Adult Antibodies, Antiphospholipid Antithrombins Metabolism Ethnology Case-control Studies Factor V Genetics Female Folic Acid Homocysteine Humans Italy Male Methylenetetrahydrofolate Reductase (nadph2) Polymorphism, Genetic Protein C Prothrombin Receptors, Lipoprotein Risk Factors Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Rheumatology |
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