NDLI: Development of a personal dual-phase air sampling method for phthalate diesters.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hines, Cynthia J. Yau, Alice Y. Zuniga, Michelle M. Wells, J. Raymond Nilsen Hopf, Nancy B. Camann, David E.
Description	Country affiliation: United States Author Affiliation: Hines CJ ( National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4776 Columbia Pkwy, R-14, Cincinnati, OH 45226, USA. chines@cdc.gov)
Abstract	Phthalates are used as plasticizers in many industrial and consumer products. Urinary biomonitoring has shown widespread human exposure to phthalates, with workers having especially high exposures. Phthalates can be present in workplace air as either aerosols or vapors depending on source materials, vapor pressure, and processing temperatures. We sought to develop a dual-phase air sampling method for 6 phthalates, dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzyl butyl phthalate (BzBP), di(2-ethylhexyl) phthalate (DEHP), and di-n-octyl phthalate (DnOP), adaptable to aerosol inlets with known particle collection characteristics. Collection media consisted of a quartz fiber filter and XAD-2 resin. Limit of detection (LOD) and limit of quantification (LOQ) were determined for each phthalate. Phthalate recoveries were evaluated at 3x, 10x and 30x the LOQ, and after storage at -21 degrees C and 21 degrees C. Media were Soxhlet extracted in 10% diethyl ether in hexanes along with an extraction surrogate, di-n-pentyl phthalate-d(4). Gas chromatography/mass spectrometry was performed to quantify the phthalate diesters using di(2-ethylhexyl) phthalate-d(4) as an internal standard. Estimated LODs were 1 microg per sample (BzBP, DEHP, and DnOP), 2 microg per sample (DMP and DBP), and 5 microg per sample (DEP). Mean recoveries under static conditions were 85-104% for DBP, BzBP, DEHP, and DnOP; but <70% for DMP and DEP at 3x and 10x the LOQ. After air was pulled through spiked samples, DMP and DEP recoveries improved to 74-81%. After storage for 62 days, phthalate recovery was better at -21 degrees C than at 21 degrees C. Method accuracy was best for DBP, BzBP, DEHP, and DnOP (range 11-18%), and less so for DMP (28%) and DEP (29%).
File Format	HTM / HTML
ISSN	14640325
Issue Number	2
Volume Number	12
e-ISSN	14640333
Journal	Journal of Environmental Monitoring
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2010-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Environmental Health Air Pollutants, Occupational Analysis Environmental Medicine Instrumentation Occupational Exposure Phthalic Acids Gas Chromatography-mass Spectrometry Humans Limit Of Detection Linear Models Journal Article Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law

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