NDLI: Epicardial Artery Stenosis with a High Index of Microcirculatory Resistance Is Frequently Functionally Insignificant as Estimated by Fractional Flow Reserve (FFR).

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Epicardial Artery Stenosis with a High Index of Microcirculatory Resistance Is Frequently Functionally Insignificant as Estimated by Fractional Flow Reserve (FFR).

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Epicardial Artery Stenosis with a High Index of Microcirculatory Resistance Is Frequently Functionally Insignificant as Estimated by Fractional Flow Reserve (FFR).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Park, Sang-Don Lee, Man-Jong Woo, Seong-Ill Baek, Yong-Soo Shin, Sung-Hee Kim, Dae-Hyeok Kwan, Jun Park, Keum-Soo
Description	Country affiliation: South Korea Author Affiliation: Park SD ( Department of Internal Medicine, Inha University Hospital, South Korea.)
Abstract	Objective Differences in microvascular integrity can diversely influence the functional assessment of epicardial coronary artery disease in each patient. We investigated the relevance of the index of microcirculatory resistance (IMR) and fractional flow reserve (FFR) of intermediate coronary lesions. Methods The IMR and FFR were measured in 67 intermediate coronary lesions of the left anterior descending artery of 67 patients, by using a pressure sensor/thermistor-tipped guidewire. Results To assess the differences in FFR in relationship to the IMR value, patients were divided into tertile IMR groups as follows: Low-IMR (n=22, IMR 14±3), Mid-IMR (n=23, IMR 21±2), and High-IMR (n=22, IMR 36±10). An analysis of variance showed that the High-IMR group had significantly higher FFR values (0.87±0.07) than the Low-IMR group (0.81±0.08) (p=0.03). Functionally significant lesions with FFR ≤0.8 accounted for 9% of lesions in the High-IMR group, 36% in the Low-IMR group and 22% in the Mid-IMR group (p=0.02). In the multivariate logistic analysis, the IMR value was an independent determinant of FFR ≤0.8 (p=0.03). Conclusion In patients with a high IMR, intermediate lesions as identified with visual estimation were more frequently functionally insignificant. The IMR can provide additional information in understanding the mismatch between the anatomical and functional severity of intermediate coronary stenosis.
File Format	HTM / HTML
ISSN	09182918
e-ISSN	13497235
Journal	Internal Medicine
Issue Number	2
Volume Number	55
Language	English
Publisher	The Japanese Society of Internal Medicine
Publisher Date	2016-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Internal Medicine Coronary Stenosis Physiopathology Diagnostic Techniques, Cardiovascular Microcirculation Physiology Vascular Resistance Multivariate Analysis Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Internal Medicine

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Epicardial Artery Stenosis with a High Index of Microcirculatory Resistance Is Frequently Functionally Insignificant as Estimated by Fractional Flow Reserve (FFR).

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Epicardial Artery Stenosis with a High Index of Microcirculatory Resistance Is Frequently Functionally Insignificant as Estimated by Fractional Flow Reserve (FFR).