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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hunt, Brendan G. Glastad, Karl M. Yi, Soojin V. Goodisman, Michael A. D. |
| Description | Country affiliation: United States Author Affiliation: Hunt BG ( School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.) |
| Abstract | Epigenetic inheritance plays a fundamentally important role in mediating gene regulation and phenotypic plasticity. DNA methylation, in particular, has been the focus of many recent studies aimed at understanding the function of epigenetic information in insects. An understanding of DNA methylation, however, requires knowledge of its context in relation to other epigenetic modifications. Here, we review recent insights into the localization of DNA methylation in insect genomes and further discuss the functional significance of these insights in the context of the greater eukaryotic epigenome. In particular, we highlight the complementarity of the eukaryotic epigenetic landscape. We focus on the importance of DNA methylation to nucleosome stability, which may explain the context-dependent associations of DNA methylation with gene expression. Ultimately, we suggest that the integration of diverse epigenetic modifications in studies of insects will greatly advance our understanding of the evolution of epigenetic systems and epigenetic contributions to developmental regulation. |
| File Format | HTM / HTML |
| ISSN | 15407063 |
| e-ISSN | 15577023 |
| Journal | Integrative and Comparative Biology |
| Issue Number | 2 |
| Volume Number | 53 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2013-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Zoology Discipline Biology Dna Methylation Physiology Dna, Intergenic Genetics Epigenesis, Genetic Genome, Insect Insects Animals Biological Evolution Evolution, Molecular Gene Expression Regulation Genes, Insect Nucleosomes Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Plant Science Medicine Animal Science and Zoology |
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