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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kalantari, Heibatullah Jalali, Mohammadtaha Jalali, Amir Salimi, Abobakr Alhalvachi, Foad Varga, Balazs Juhasz, Bela Jakab, Anita Kemeny-Beke, Adam Gesztelyi, Rudolf Tosaki, Arpad Zsuga, Judit |
| Description | Country affiliation: Iran Author Affiliation: Kalantari H ( School of Pharmacy, Toxicology Center, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran.) |
| Abstract | The efficacy of a crude hydro-alcoholic extract of Cassia fistula (golden shower tree) fruit to protect the kidney against bromobenzene-induced toxicity was studied. Negative control mice received normal saline; positive control mice were given 460 mg/kg of bromobenzene; Cassia fistula treated mice received 200, 400, 600 and 800 mg/kg of Cassia fistula fruit extract followed by 460 mg/kg bromobenzene (daily by oral gavage for 10 days). On the 11th day, the mice were sacrificed, blood samples were obtained to assess blood urea nitrogen (BUN) and creatinine levels, and kidneys were removed for histological examination. We found that bromobenzene induced significant nephrotoxicity reflected by an increase in levels of BUN and creatinine that was dose dependently prevented by the Cassia fistula fruit extract. The nephroprotective effect of the Cassia fistula fruit extract was confirmed by the histological examination of the kidneys. To the best of our knowledge, this is the first study to demonstrate the protective effect of Cassia fistula in nephrotoxicity. |
| File Format | HTM / HTML |
| ISSN | 09603271 |
| Issue Number | 10 |
| Volume Number | 30 |
| e-ISSN | 14770903 |
| Journal | Human & Experimental Toxicology |
| Language | English |
| Publisher | Sage Publication |
| Publisher Date | 2011-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Toxicology Bromobenzenes Toxicity Cassia Chemistry Kidney Drug Effects Plant Extracts Pharmacology Protective Agents Animals Blood Urea Nitrogen Creatinine Blood Fruit Pathology Male Mice Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology |
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