NDLI: Dual effects of erdosteine on hemostasis via its different metabolites in young rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Arica, Vefik Tutanc, Murat Ozturk, Oktay Hasan Arica, Secil Basarslan, Fatmagul Erden, Ersin Sukru Oktar, Suleyman Kaya, Hasan
Description	Country affiliation: Turkey Author Affiliation: Arica V ( Department of Pediatrics, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey. vefikarica@hotmail.com)
Abstract	AIM: In the study, we examined erdosteine's effects on platelet functions and coagulation. MATERIALS AND METHODS: A total 29 young albino Wistar rats were divided into four groups. Control rats (n = 6) were given saline; Group 1 rats (n = 7) were given 3 mg/kg erdosteine by oral gavage for 3 days; Group 2 rats (n = 7) were given 10 mg/kg erdosteine by oral gavage for 3 days; and Group 3 rats (n = 9) were given 30 mg/kg erdosteine for 3 days. Twenty-four hours after the final dose, blood samples were drawn from a portal vein. Prothrombin time (PT), activated partial thromboplastin time (aPTT) and international normalized ratio (INR) were measured, and platelet counts were examined in a peripheral blood smear by light microscopy. RESULTS: PT and INR values of Group 1 increased compared to the controls but did not change in Group 3. Hemostatic parameters were not measured in Group 2 because the blood samples in Group 2's tubes clotted rapidly. Platelet counts of the peripheral blood from Group 2 were low but were normal in other groups. CONCLUSION: We have concluded erdosteine may disrupt hemostasis parameters by its different metabolites in patients. Erdosteine has dual effects on hemostasis via its different metabolites, which occur in different doses.
File Format	HTM / HTML
ISSN	09603271
Issue Number	10
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Expectorants Pharmacology Hemostasis Drug Effects Thioglycolates Thiophenes Animals International Normalized Ratio Platelet Count Prothrombin Time Rats Rats, Wistar Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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