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Population and forensic genetic analyses of mitochondrial DNA control region variation from six major provinces in the Korean population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hong, Seung Beom Kim, Ki Cheol Kim, Wook
Spatial Coverage	Republic of Korea
Description	Author Affiliation: Hong SB ( Department of Biological Sciences, Dankook University, Cheonan 330-714, Republic of Korea); Kim KC ( Department of Biological Sciences, Dankook University, Cheonan 330-714, Republic of Korea.); Kim W ( Department of Biological Sciences, Dankook University, Cheonan 330-714, Republic of Korea. Electronic address: wookkim@dankook.ac.kr.)
Abstract	We generated complete mitochondrial DNA (mtDNA) control region sequences from 704 unrelated individuals residing in six major provinces in Korea. In addition to our earlier survey of the distribution of mtDNA haplogroup variation, a total of 560 different haplotypes characterized by 271 polymorphic sites were identified, of which 473 haplotypes were unique. The gene diversity and random match probability were 0.9989 and 0.0025, respectively. According to the pairwise comparison of the 704 control region sequences, the mean number of pairwise differences between individuals was 13.47±6.06. Based on the result of mtDNA control region sequences, pairwise FST genetic distances revealed genetic homogeneity of the Korean provinces on a peninsular level, except in samples from Jeju Island. This result indicates there may be a need to formulate a local mtDNA database for Jeju Island, to avoid bias in forensic parameter estimates caused by genetic heterogeneity of the population. Thus, the present data may help not only in personal identification but also in determining maternal lineages to provide an expanded and reliable Korean mtDNA database. These data will be available on the EMPOP database via accession number EMP00661.
File Format	HTM / HTML
ISSN	18724973
Volume Number	17
e-ISSN	18780326
Journal	Forensic Science International: Genetics
Language	English
Publisher	Elsevier
Publisher Date	2015-07-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Forensic Sciences Dna, Mitochondrial Genetics Asian Continental Ancestry Group Blood Databases, Genetic Ethnic Groups Forensic Genetics Methods Genetic Variation Genetics, Population Haplotypes Humans Polymerase Chain Reaction Polymorphism, Genetic Drug Effects Republic Of Korea Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Pathology and Forensic Medicine

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