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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Alghafri, Rashed Goodwin, Will Ralf, Arwin Kayser, Manfred Hadi, Sibte |
| Description | Country affiliation: United Arab Emirates Author Affiliation: Alghafri R ( University of Central Lancashire, School of Forensic and Investigative Sciences, Preston, UK); Goodwin W ( University of Central Lancashire, School of Forensic and Investigative Sciences, Preston, UK.); Ralf A ( Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.); Kayser M ( Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.); Hadi S ( University of Central Lancashire, School of Forensic and Investigative Sciences, Preston, UK. Electronic address: shadi@uclan.ac.uk.) |
| Abstract | A multiplex polymerase chain reaction (PCR) assay (RM-Yplex) was developed which is capable of simultaneously amplifying 13 recently introduced rapidly mutating Y-STR markers (RM Y-STRs). This multiplex assay is expected to aid human identity testing in forensic and other applications to improve differentiating unrelated males and allow separating related males. The 13 RM Y-STR markers included in the multiplex are: DYF387S1, DYF399S1, DYF403S1ab, DYF404S1, DYS449, DYS518, DYS526ab, DYS547, DYS570, DYS576, DYS612, DYS626 and DYS627. This study reflects the proof of concept to analyse all currently known RM Y-STRs simultaneously and describes the optimization of the multiplex assay. The RM-Yplex assay generated complete RM Y-STR profiles down to 62.5pg of male template DNA, and from male-female DNA mixtures at all ratios tested. We herewith introduce and make available for widespread use in forensic and anthropological studies, an effective and sensitive single multiplex assay for simultaneous genotyping of 13 RM Y-STRs. |
| File Format | HTM / HTML |
| ISSN | 18724973 |
| Volume Number | 17 |
| e-ISSN | 18780326 |
| Journal | Forensic Science International: Genetics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Forensic Sciences Chromosomes, Human, Y Microsatellite Repeats Multiplex Polymerase Chain Reaction Methods Mutation Alleles Forensic Genetics Haplotypes Humans Male Evaluation Studies Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Pathology and Forensic Medicine |
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