NDLI: Synergistic effects and physiological responses of selected bacterial isolates from animal feed to four natural antimicrobials and two antibiotics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, DongLai Hu, HuiPing Rao, QinXiong Zhao, ZhiHui
Description	Author Affiliation: Zhang D ( Institute of Agri-Food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, 2901 BeiDi Road, Shanghai, P.R. China. zhangdl2156256@hotmail.com)
Abstract	In this study, 20 samples from three different sources of animal feed were investigated and six bacterial isolates were identified. The susceptibility of four natural antimicrobials, namely, eugenol, cinnamaldehyde, thymol, and carvacrol, against six of these isolates was determined. Carvacrol and eugenol showed better inhibitory effects with larger zones of inhibition. The minimal inhibitory concentration for a range of antibiotics on the susceptibility of two isolates (namely, Sphingomonas paucimobilis and Klebsiella oxytoca) was investigated using the VITEK® 2 microbiological identification system. Both isolates showed a variety of resistance to 18 antibiotics. The minimal inhibitory concentration and fractional inhibitory concentration index of those two isolates for ampicillin and nitrofurantoin in combination with four phenolic compounds was determined. Synergistic interactions were found for most antimicrobial/antibiotic combinations; thymol and carvacrol were very effective (fractional inhibitory concentration ≤0.5) in combination with all antibiotics tested against S. paucimobilis and K. oxytoca, respectively. Ultra performance liquid chromatography techniques were used to investigate the physiological effects of the four natural antimicrobials against those two isolates. Two identical peaks were found to be systematically different between cinnamaldehyde-treated and -untreated cells. The identity of the peaks is unknown and further investigation is needed.
File Format	HTM / HTML
ISSN	15353141
Issue Number	10
Volume Number	8
e-ISSN	15567125
Journal	Foodborne Pathogens and Disease
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2011-10-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Microbiology Discipline Parasitology Discipline Nutritional Sciences Animal Feed Microbiology Anti-infective Agents Pharmacology Drug Resistance, Bacterial Klebsiella Oxytoca Drug Effects Plant Extracts Sphingomonas Acrolein Analogs & Derivatives Ampicillin Animals Cattle Dose-response Relationship, Drug Drug Synergism Ducks Eugenol Food Microbiology Physiology Microbial Sensitivity Tests Monoterpenes Nitrofurantoin Quorum Sensing Swine Thymol Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology Microbiology Applied Microbiology and Biotechnology Food Science

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