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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Salvucci, Emiliano Saavedra, Lucila Hebert, Elvira Maria Haro, Cecilia Sesma, Fernando |
| Description | Country affiliation: Argentina Author Affiliation: Salvucci E ( Centro de Referencia para Lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Tucumán, Argentina.) |
| Abstract | Listeria monocytogenes is a foodborne pathogen causative of opportunistic infections. Listeriosis is associated with severe infections in pregnant women causing abortion or neonatal listeriosis. An alternative to antibiotics are safe novel bacteriocins peptides such as enterocin CRL35 with strong antilisterial activity produced by Enterococcus mundtii CRL35. In the present paper, our goal is to study the effectiveness of this peptide and the producer strain in a murine model of pregnancy-associated listeriosis. A single dose of 5×10(9) colony-forming unit of L. monocytogenes FBUNT (Faculty of Biochemistry-University of Tucumán) resulted in translocation of pathogen to liver and spleen of BALB/c pregnant mice. The maximum level of Listeria was observed on day 3 postinfection. Interestingly, the intragastric administration of enterocin CRL35 significantly reduced the translocation of the pathogen to vital organs. On the other hand, the preadministration of E. mundtii CRL35 slightly inhibited this translocation. Listeria infection caused a significant increase in polymorphonuclear leukocytes at day 3 postinfection compared to the noninfected group. This value was reduced after the administration of enterocin CRL35. No significant changes were observed in either white blood cells or lymphocytes counts. Based on the data presented in the present work enterocin CRL35 would be a promising alternative for the prevention of Listeria infections. |
| File Format | HTM / HTML |
| ISSN | 15353141 |
| Issue Number | 1 |
| Volume Number | 9 |
| e-ISSN | 15567125 |
| Journal | Foodborne Pathogens and Disease |
| Language | English |
| Publisher | Mary Ann Liebert, Inc. |
| Publisher Date | 2012-01-01 |
| Publisher Place | United States |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Microbiology Discipline Parasitology Discipline Nutritional Sciences Anti-bacterial Agents Pharmacology Bacteriocins Enterococcus Chemistry Listeria Monocytogenes Drug Effects Listeriosis Prevention & Control Pregnancy Complications, Infectious Administration, Oral Animals Isolation & Purification Therapeutic Use Female Humans Leukocytes Leukocytosis Blood Growth & Development Microbiology Mice Mice, Inbred Balb C Peptides Pregnancy Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Animal Science and Zoology Microbiology Applied Microbiology and Biotechnology Food Science |
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