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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rico-Villademoros, Fernando Slim, Mahmoud Calandre, Elena P. |
| Description | Country affiliation: Spain Author Affiliation: Rico-Villademoros F ( a Universidad de Granada, Instituto de Neurociencias, Granada, Spain.); Slim M ( a Universidad de Granada, Instituto de Neurociencias, Granada, Spain.) |
| Abstract | Fibromyalgia is characterized by chronic generalized pain accompanied by a wide range of clinical manifestations. Most clinical practice guidelines recommend multidisciplinary treatment using a combination of pharmacological and non-pharmacological therapies. The tricyclic antidepressant amitriptyline has been most thoroughly studied in fibromyalgia. Amitriptyline has been evaluated in placebo-controlled studies, and it has served as an active comparator to other therapeutic interventions in the treatment of fibromyalgia. In addition, several systematic reviews and meta-analyses have evaluated its efficacy and safety for the treatment of fibromyalgia. Data from individual studies as well as from systematic reviews indicate that low doses (10-75 mg/day) of amitriptyline are effective for the treatment of fibromyalgia and, despite the limited quality of the data, they do not seem to be associated with relevant tolerability or safety issues. Consistent with some clinical guidelines, we believe amitriptyline in low doses should be considered a first-line drug for the treatment of fibromyalgia. |
| File Format | HTM / HTML |
| ISSN | 14737175 |
| Issue Number | 10 |
| Volume Number | 15 |
| e-ISSN | 17448360 |
| Journal | Expert Review of Neurotherapeutics |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Neurology Amitriptyline Therapeutic Use Fibromyalgia Drug Therapy Adverse Effects Pharmacokinetics Antidepressive Agents, Tricyclic Metabolism Humans Randomized Controlled Trials As Topic Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Neurology (clinical) Pharmacology (medical) |
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