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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bari, Ausaf A. Fasano, Alfonso Munhoz, Renato P. Lozano, Andres M. |
| Description | Country affiliation: Canada Author Affiliation: Bari AA ( a 1 Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Krembil Neuroscience Center, University of Toronto, Toronto, ON M5T 2S8, Canada.); Fasano A ( b 2 Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada.); Munhoz RP ( b 2 Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, Canada.); Lozano AM ( a 1 Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Krembil Neuroscience Center, University of Toronto, Toronto, ON M5T 2S8, Canada.) |
| Abstract | The subthalamic nucleus (STN) has been a major target of deep brain stimulation (DBS) for Parkinson's disease (PD) over the past 20 years. The benefits of DBS of the STN include: decreased motor fluctuations and bradykinesia, tremor reduction and a reduction in dopaminergic drug requirements and dyskinesias. Despite these overall positive effects, the outcomes of STN DBS can be variable, contributing to the debate over the best DBS target for PD. Here, the authors review the current practice of STN DBS and also review both the existing and emerging technologies that are likely to improve the accuracy and effectiveness of STN DBS for PD. The authors emphasize patient selection, accuracy of electrode placement within the brain and the selection of appropriate stimulation parameters to optimize clinical benefits. |
| File Format | HTM / HTML |
| ISSN | 14737175 |
| Issue Number | 10 |
| Volume Number | 15 |
| e-ISSN | 17448360 |
| Journal | Expert Review of Neurotherapeutics |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Neurology Deep Brain Stimulation Methods Parkinson Disease Therapy Subthalamic Nucleus Physiology Humans Physiopathology Treatment Outcome Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Neurology (clinical) Pharmacology (medical) |
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