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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sonpavde, Guru Palapattu, Ganesh S. |
| Description | Country affiliation: United States Author Affiliation: Sonpavde G ( Texas Oncology, Baylor College of Medicine, TX, USA. guru.sonpavde@usoncology.com) |
| Abstract | Neoadjuvant therapy improves outcomes for a number of malignancies and provides intermediate pathologic outcomes, which correlate with long-term outcomes. Neoadjuvant androgen-deprivation therapy, alone or with docetaxel chemotherapy, preceding prostatectomy for localized prostate cancer is feasible and demonstrates pathologic activity, but evidence for improved long-term outcomes is lacking. Data in support of the further exploration of neoadjuvant therapy for localized prostate cancer preceding prostatectomy are reviewed. Ongoing randomized trials are elucidating the impact of neoadjuvant androgen deprivation combined with docetaxel chemotherapy on pathologic and long-term outcomes. The correlation of pathologic and biologic outcomes with long-term outcomes in this setting is unknown. The neoadjuvant therapy approach followed by prostatectomy is feasible with a wide array of agents and provides a paradigm for evaluating the activity, and mechanism of action and resistance to new treatments. This promising modality may aid the rapid development of novel therapeutic agents. A multidisciplinary approach involving oncologists, urologists and pathologists is critical to the success of this model. |
| File Format | HTM / HTML |
| ISSN | 14737140 |
| Issue Number | 3 |
| Volume Number | 10 |
| e-ISSN | 17448328 |
| Journal | Expert Review of Anticancer Therapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Oncology Antineoplastic Agents Therapeutic Use Neoadjuvant Therapy Methods Prostatic Neoplasms Drug Therapy Androgen Antagonists Combined Modality Therapy Humans Male Prostatectomy Surgery Randomized Controlled Trials As Topic Taxoids Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
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