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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Niscola, Pasquale Scaramucci, Laura Romani, Claudio Giovannini, Marco Tendas, Andrea Brunetti, Gregorio Cartoni, Claudio Palumbo, Roberto Vischini, Gisella Siniscalchi, Agostina de Fabritiis, Paolo Caravita, Tommaso |
| Description | Country affiliation: Italy Author Affiliation: Niscola P ( Division of Haematology, S. Eugenio Hospital, Rome, Italy. pniscola@gmail.com) |
| Abstract | Pain is a prominent feature of multiple myeloma (MM) and may be caused by different underlying causes and mechanisms. Indeed, pain may be due to disease-related complications, iatrogenic causes or may be associated with other unrelated medical conditions. This symptom may be particularly devastating and can negatively affect the quality of life of the afflicted patients and their functional status. For most MM patients suffering from continuous nociceptive pain, the WHO's three-step analgesic ladder can provide adequate relief with oral options, although the high prevalence in MM patients of difficult-to-treat pains, such as pains due to skeletal mechanical instability or sustained by neuropathic mechanisms, makes the treatment approach a challenging concern. The management of pain in this setting requires a multidisciplinary approach integrating analgesics and causal interventions. This review focuses on the most common syndromes afflicting MM patients, attempting to provide an understanding of the underlying pain mechanisms and a discussion of the most commonly used treatment strategies. |
| File Format | HTM / HTML |
| ISSN | 14737140 |
| Issue Number | 3 |
| Volume Number | 10 |
| e-ISSN | 17448328 |
| Journal | Expert Review of Anticancer Therapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2010-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Oncology Analgesics Therapeutic Use Multiple Myeloma Complications Pain Drug Therapy Administration, Oral Administration & Dosage Pharmacology Humans Epidemiology Etiology Practice Guidelines As Topic Prevalence Quality Of Life World Health Organization Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
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