NDLI: Molekulardiagnostik zur Therapiestratifizierung des Lungenkarzinoms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Heukamp, L. C. Wolf, J. Büttner, R.
Description	Author Affiliation: Heukamp LC ( Institut für Pathologie, Universitätsklinikum Köln, Köln, Köln. Lukas.heukamp@uk-koeln.de)
Abstract	Lung tumors continue to be the most frequent cause of cancer-related death in Western industrialized countries. The development of new chemotherapeutic substances that are directed specifically against oncogenic pathomechanisms of non-small cell lung cancer represents a promising therapeutic approach. Meanwhile treatment measures are being employed for pulmonary adenocarcinomas that target the epidermal growth factor receptor and transforming EML4-ALK fusion protein. However, these therapies benefit almost exclusively those patients who have never smoked and manifest relatively rare subtypes of adenocarcinomas. In contrast, targeted therapeutic options for squamous cell carcinomas of the lung frequently found in smokers are still limited, although amplifications of the fibroblast growth factor receptor 1 have recently been identified as possible therapeutic targets in this patient population. This contribution provides an overview of the underlying pathomechanisms and molecular diagnostics needed for treatment stratification.
File Format	HTM / HTML
ISSN	00209554
Issue Number	2
Journal	Der Internist
Volume Number	52
e-ISSN	14321289
Language	German
Publisher	Springer
Publisher Date	2011-02-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Internal Medicine Drug Delivery Systems Methods Lung Neoplasms Diagnosis Drug Therapy Molecular Diagnostic Techniques Humans English Abstract Journal Article
Alternative Title	Molecular diagnostics of lung cancer for treatment stratification
Content Type	Text
Resource Type	Article
Subject	Internal Medicine

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