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The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: a meta-analysis of randomized controlled trials.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Varadhan, Krishna K. Neal, Keith R. Dejong, Cornelius H. C. Fearon, Kenneth C. H. Ljungqvist, Olle Lobo, Dileep N.
Description	Country affiliation: United kingdom Author Affiliation: Varadhan KK ( Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen's Medical Centre, Nottingham NG7 2 UH, UK.)
Abstract	BACKGROUND & AIMS: The aim of the Enhanced Recovery After Surgery (ERAS) pathway is to attenuate the stress response to surgery and enable rapid recovery. The objective of this meta-analysis was to study the differences in outcomes in patients undergoing major elective open colorectal surgery within an ERAS pathway and those treated with conventional perioperative care. METHODS: Medline, Embase and Cochrane database searches were performed for relevant studies published between January 1966 and November 2009. All randomized controlled trials comparing ERAS with conventional perioperative care were selected. The outcome measures studied were length of hospital stay, complication rates, readmission rates and mortality. RESULTS: Six randomized controlled trials with 452 patients were included. The number of individual ERAS elements used ranged from 4 to 12, with a mean of 9. The length of hospital stay [weighted mean difference (95% confidence interval): -2.55 (-3.24, -1.85)] and complication rates [relative risk (95% confidence interval): 0.53 (0.44, 0.64)] were significantly reduced in the enhanced recovery group. There was no statistically significant difference in readmission and mortality rates. CONCLUSION: ERAS pathways appear to reduce the length of stay and complication rates after major elective open colorectal surgery without compromising patient safety.
File Format	HTM / HTML
ISSN	02615614
Issue Number	4
Volume Number	29
e-ISSN	15321983
Journal	Clinical Nutrition
Language	English
Publisher	Elsevier
Publisher Date	2010-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Sciences Colonic Diseases Surgery Elective Surgical Procedures Adverse Effects Perioperative Care Rectal Diseases Adult Aged Aged, 80 And Over Mortality Humans Length Of Stay Statistics & Numerical Data Middle Aged Patient Readmission Postoperative Complications Prevention & Control Randomized Controlled Trials As Topic Treatment Outcome Young Adult Journal Article Meta-analysis Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Critical Care and Intensive Care Medicine

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