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Loss of adipose tissue and plasma phospholipids: relationship to survival in advanced cancer patients.

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Year: 2010 Volume: 29 Issue: 3

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Year: 2008 Volume: 27

Year: 2007 Volume: 26

Loss of adipose tissue and plasma phospholipids: relationship to survival in advanced cancer patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Murphy, R. A. Wilke, M. S. Perrine, M. Pawlowicz, M. Mourtzakis, M. Lieffers, J. R. Maneshgar, M. Bruera, E. Clandinin, M. T. Baracos, V. E. Mazurak, V. C.
Description	Country affiliation: Canada Author Affiliation: Murphy RA ( Alberta Institute for Human Nutrition, University of Alberta, 4-10 Agriculture/Forestry Centre Edmonton, Alberta, T6G 2P5, Canada.)
Abstract	BACKGROUND & AIMS: Extensive loss of adipose tissue is a key feature of cancer cachexia. Advanced cancer patients also exhibit low plasma phospholipids. It is not known whether these processes coincide across the cancer trajectory nor has their relationship with survival been defined. Changes in adipose tissue mass and plasma phospholipids were characterized within 500days prior to death and prognostic significance assessed. METHODS: Adipose tissue rate of change was determined in a retrospective cohort of patients who died of colorectal and lung cancers (n=108) and who underwent >2 computed tomography scans in the last 500days of life. Plasma phospholipid fatty acids were measured prospectively in a similar cohort of patients with metastatic cancer (n=72). RESULTS: Accelerated loss of adipose tissue begins at 7months from death reaching an average loss of 29% of total AT 2months from death. Plasma phospholipid fatty acids were 35% lower in patients closest to death versus those surviving >8months. Losses of phospholipid fatty acids and adipose tissue occur in tandem and are predictive of survival. CONCLUSIONS: Depletion of plasma phospholipids likely indicates a deficit of essential fatty acids in the periphery which may contribute to loss of adipose tissue.
File Format	HTM / HTML
ISSN	02615614
Issue Number	4
Volume Number	29
e-ISSN	15321983
Journal	Clinical Nutrition
Language	English
Publisher	Elsevier
Publisher Date	2010-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Sciences Adipose Tissue, White Metabolism Adiposity Cachexia Lipolysis Neoplasms Physiopathology Phospholipids Blood Aged Diagnosis Epidemiology Cohort Studies Disease Progression Fatty Acids Female Humans Intra-abdominal Fat Male Middle Aged Muscle, Skeletal Neoplasm Metastasis Prognosis Retrospective Studies Subcutaneous Fat Survival Analysis Journal Article
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Critical Care and Intensive Care Medicine

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