NDLI: The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).

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The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Steinert, R. E. Gerspach, A. C. Gutmann, H. Asarian, L. Drewe, J. Beglinger, C.
Description	Country affiliation: Switzerland Author Affiliation: Steinert RE ( Clinical Research Center, Department of Biomedicine, Switzerland. robert.steinert@unibas.ch)
Abstract	BACKGROUND & AIMS: Enteroendocrine cells are thought to directly sense nutrients via -gustducin coupled taste receptors (originally identified in the oral epithelium) to modulate the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). METHODS: We measured mRNA expression of -gustducin and T1R3 along the human gut; immunohistochemistry was used to confirm co-localization with GLP-1. Functional implication of sweet taste receptors in glucose-stimulated secretion of GLP-1 and PYY was determined by intragastric infusion of glucose with or without lactisole (a sweet taste receptor antagonist) in 16 healthy subjects. RESULTS: -gustducin was expressed in a region-specific manner (predominantly in the proximal gut and less in ileum and colon, P < 0.05). Both, T1R3 and -gustducin were co-localized with GLP-1. Glucose-stimulated secretions of GLP-1 (P = 0.026) and PYY (P = 0.034) were reduced by blocking sweet receptors with lactisole. CONCLUSION: Key proteins implicated in taste signaling are present in the human gut and co-localized with GLP-1 suggesting that these proteins are functionally linked to peptide secretion from enteroendocrine cells. Glucose-stimulated secretion of GLP-1 and PYY is reduced by a sweet taste antagonist, suggesting the functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of both peptides in humans.
File Format	HTM / HTML
ISSN	02615614
Issue Number	4
Volume Number	30
e-ISSN	15321983
Journal	Clinical Nutrition
Language	English
Publisher	Elsevier
Publisher Date	2011-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Sciences Colon Drug Effects Glucagon-like Peptide 1 Secretion Glucose Metabolism Ileum Peptide Yy Adult Aged Benzene Derivatives Administration & Dosage Enteroendocrine Cells Female Genetics Humans Immunohistochemistry Male Middle Aged Rna, Messenger Receptors, G-protein-coupled Antagonists & Inhibitors Taste Transducin Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Critical Care and Intensive Care Medicine

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