NDLI: Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

Content Provider	PubMed Central
Author	Jang, Hyeung-jin Zaza, Kokrashvili Theodorakis, Michael J. Carlson, Olga D. Kim, Byung-joon Zhou, Jie Kim, Hyeon Ho Xu, Xiangru Chan, Sic L. Magdalena, Juhaszova Bernier, Michel Mosinger, Bedrich Margolskee, Robert F. Egan, Josephine M.
Copyright Year	2007
Abstract	Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protein gustducin, and several other taste transduction elements. Mouse intestinal L cells also express α-gustducin. Ingestion of glucose by α-gustducin null mice revealed deficiencies in secretion of GLP-1 and the regulation of plasma insulin and glucose. Isolated small bowel and intestinal villi from α-gustducin null mice showed markedly defective GLP-1 secretion in response to glucose. The human L cell line NCI-H716 expresses α-gustducin, taste receptors, and several other taste signaling elements. GLP-1 release from NCI-H716 cells was promoted by sugars and the noncaloric sweetener sucralose, and blocked by the sweet receptor antagonist lactisole or siRNA for α-gustducin. We conclude that L cells of the gut “taste” glucose through the same mechanisms used by taste cells of the tongue. Modulating GLP-1 secretion in gut “taste cells” may provide an important treatment for obesity, diabetes and abnormal gut motility.
Related Links	http://dx.doi.org/10.1073/pnas.0706890104
Starting Page	15069
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	38
Volume Number	104
Language	English
Publisher	National Academy of Sciences
Publisher Date	2007-09-18
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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