NDLI: Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia.

Please wait, while we are loading the content...

Year: 2017 Volume: 28

Year: 2016 Volume: 27

Year: 2015 Volume: 26

Year: 2014 Volume: 25

Year: 2013 Volume: 24

Year: 2012 Volume: 23

Year: 2011 Volume: 22

Year: 2010 Volume: 21

Year: 2010 Volume: 21 Issue: 8

Year: 2010 Volume: 21 Issue: 7

Year: 2010 Volume: 21 Issue: 6

Year: 2010 Volume: 21 Issue: 5

Year: 2010 Volume: 21 Issue: 4

A diagnostic challenge: mild hemophilia B with normal activated partial thromboplastin time.

Migrating venous thrombosis in acute leukemia.

Fibrinolytic parameters in children with noncatheter thrombosis: a pilot study.

Analysis of factor VIIa binding to relipidated tissue factor by surface plasmon resonance.

Neonatal and childhood right atrial thrombosis: recognition and a risk-stratified treatment approach.

Hemodialysis catheter: induced giant right atrial thrombus.

Molecular genetic analysis of Korean patients with coagulation factor XII deficiency.

Thrombophilic factors in idiopathic intracranial hypertension: a report of 51 patients and a meta-analysis.

Tissue plasminogen activator induced fibrinolysis: standardization of method using thromboelastography.

Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia.

The use of Ankaferd blood stopper in a patient with Glanzmann's thrombasthenia with gingival bleeding.

Year: 2010 Volume: 21 Issue: 3

Year: 2010 Volume: 21 Issue: 2

Year: 2010 Volume: 21 Issue: 1

Year: 2010 Volume: 21 Issue: Supplementary 1

Year: 2009 Volume: 20

Year: 2008 Volume: 19

Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yilmaz, Zeki Ozarda, Yesim Cansev, Mehmet Eralp, Oya Kocaturk, Meric Ulus, Ismail H.
Description	Author Affiliation: Yilmaz Z ( Department of Internal Medicine, Turkey, Uludag University, Bursa, Turkey. zyilmaz@uludag.edu.tr )
Abstract	Sepsis/endotoxemia causes platelet dysfunctions, abnormalities in coagulation and hemostatic mechanisms leading to organ dysfunctions and mortality. Choline prevents organ injury and improves survival during endotoxemia. The main objective of the present study was to determine the effects of choline or cytidine-5'-diphosphocholine (CDP-choline) on endotoxin-induced activation of coagulation and development of disseminated intravascular coagulation (DIC). Dogs were treated intravenously (i.v.) with saline, choline (20 mg/kg), or CDP-choline (70 mg/kg) three times with 4-h intervals starting 5 min before i.v. injection of endotoxin (1 mg/kg). Platelet counts and functions, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, coagulation factors, D-dimer and antithrombin (AT) were measured before and at 0.5-96 h after endotoxin. Circulating platelet, fibrinogen, coagulation factors and AT were decreased, whereas PT and aPTT were prolonged and serum D-dimer levels were elevated after endotoxin. Endotoxin-induced reductions in platelet counts and functions, fibrinogen, coagulation factors and AT were attenuated or blocked by choline or CDP-choline. Choline or CDP-choline blocked endotoxin-induced prolongation in PT and aPTT and enhancement in D-dimer. Elevated DIC scores were attenuated by choline and blocked by CDP-choline. Choline administration increased serum choline concentrations and caused bradycardia. Choline also increased choline and acetylcholine contents of circulating mononuclear cells and inhibited radioligand binding to their cholinergic receptors. These data show that choline administration, as choline chloride or CDP-choline, restores the abnormalities in the primary, secondary, and tertiary hemostasis and prevents the development of DIC during experimental endotoxemia in dogs probably by increasing both neuronal and non-neuronal cholinergic activity.
File Format	HTM / HTML
ISSN	09575235
Issue Number	4
Volume Number	21
e-ISSN	14735733
Journal	Blood Coagulation & Fibrinolysis
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2010-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Hematology Blood Coagulation Drug Effects Choline Therapeutic Use Cytidine Diphosphate Choline Disseminated Intravascular Coagulation Prevention & Control Endotoxemia Complications Animals Dogs Chemically Induced Endotoxins Female Male Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hematology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in