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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kupesiz, Alphan Rajpurkar, Madhvi Warrier, Indira Hollon, Wendy Tosun, Ozgur Lusher, Jeanne Chitlur, Meera |
| Description | Country affiliation: Turkey Author Affiliation: Kupesiz A ( Department of Pediatrics, Akdeniz University School of Medicine, Antalya, Turkey.) |
| Abstract | Fibrinolysis is a complex physiological process that involves the interaction of several anticoagulant proteins. Defects of the fibrinolytic system are extremely difficult to diagnose and study because there are no standardized tests available. Thromboelastography is a novel method that allows the study of both coagulation and fibrinolysis using one sample of whole blood, thereby allowing a more physiologic assessment of the coagulation process. Several in-vitro studies have been attempted to determine whether thromboelastography would be a useful assay for the study of fibrinolysis but have reported problems with reproducibility and reliability. Here we report the process involved in developing a thromboelastographic assay in which tissue plasminogen activator (t-PA) is used to induce fibrinolysis. The assay was standardized to ensure that the concentration of the coagulation inducer (tissue factor) and fibrinolytic agent (t-PA) was adequate to induce a clot with lysis parameters that were reproducible and reliable. This method can be used to rapidly assess the intrinsic fibrinolytic potential of whole blood. Our assay showed that it could rapidly predict high levels of plasminogen activator inhibitor, and this information would be beneficial in patients with acute stroke or myocardial infarction. |
| File Format | HTM / HTML |
| ISSN | 09575235 |
| Issue Number | 4 |
| Volume Number | 21 |
| e-ISSN | 14735733 |
| Journal | Blood Coagulation & Fibrinolysis |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2010-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Hematology Fibrinolysis Thrombelastography Methods Tissue Plasminogen Activator Metabolism Blood Coagulation Humans Plasminogen Activators Antagonists & Inhibitors Reproducibility Of Results Standards Evaluation Studies Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
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