NDLI: Influenza A virus infection activates cholesterol sulfotransferase (SULT2B1b) in the lung of female C57BL/6 mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Yue Chen, Xinrong Zhang, Shunfen Chen, Guangping
Description	Country affiliation: United States Author Affiliation: Chen Y ( Department of Physiological Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74078, USA.)
Abstract	Cytosolic sulfotransferases (SULTs) catalyze the sulfation of hormones, neurotransmitters, and xenobiotics, increasing their water solubility. SULTs are not only important for xenobiotic detoxification but they also play important biological roles in the regulation of the activities of various biosignaling molecules and other cellular functions. In this study, we investigated the effects of influenza A virus lung infection on the expression of SULTs in the lung, brain, and liver of female C57BL/6 mice. Our results demonstrate for the first time that SULT2B1b enzyme activity and protein expression are significantly up-regulated in the lung and brain of female mice in response to lung influenza A virus infection. Real-time quantitative PCR results are consistent with Western blot and enzymatic activity data. In mouse liver, mSULT2B1b is not significantly changed. Enzyme activities, protein expression, and mRNA expression of SULT1A1 and SULT2A1 in the lung, brain, and liver of mice were not significantly affected by the infection. The induction of SULT2B1b may be used to inactivate natural liver X receptor ligands and activate the proliferation of T cells in response to influenza A virus infection in the lung and brain of mice. Our results raise the possibility that regulation of SULT2B1b may influence acquired immune responses to infectious diseases.
File Format	HTM / HTML
ISSN	14316730
Issue Number	10
Volume Number	392
e-ISSN	14374315
Journal	Biological Chemistry
Language	English
Publisher	Walter de Gruyter
Publisher Date	2011-10-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Biochemistry Host-pathogen Interactions Influenza A Virus Physiology Lung Enzymology Orthomyxoviridae Infections Sulfotransferases Metabolism Animals Blotting, Western Enzyme Activation Female Mice Mice, Inbred C57bl Rna, Messenger Genetics Real-time Polymerase Chain Reaction Up-regulation Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry Biochemistry Molecular Biology

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