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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hemdan, Nasr Y. A. Birkenmeier, Gerd Wichmann, Gunnar Abu El-Saad, Ahmed M. Krieger, Thorsten Conrad, Karsten Sack, Ulrich |
| Description | Country affiliation: Egypt Author Affiliation: Hemdan NY ( Department of Zoology, Faculty of Science, University of Alexandria, Egypt. nhemdan@yahoo.de) |
| Abstract | With all the incredible progress in scientific research over the past two decades, the trigger of the majority of autoimmune disorders remains largely elusive. Research on the biology of T helper type 17 (T(H)17) cells over the last decade not only clarified previous observations of immune regulations and disease manifestations, but also provided considerable information on the signaling pathways mediating the effects of this lineage and its seemingly dual role in fighting the invading pathogens on one hand, and in frightening the host by inducing chronic inflammation and autoimmunity on the other hand. In this context, recent reports have implicated T(H)17 cells in mediating host defense as well as a growing list of autoimmune diseases in genetically-susceptible individuals. Herein, we summarize the current knowledge on T(H)17 in autoimmunity with emphasis on its differentiation factors and some mechanisms involved in initiating pathological events of autoimmunity. |
| File Format | HTM / HTML |
| ISSN | 15689972 |
| Issue Number | 11 |
| Volume Number | 9 |
| e-ISSN | 18730183 |
| Journal | Autoimmunity Reviews |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Autoimmune Diseases Immunology Autoimmunity Interleukin-17 Signal Transduction Th17 Cells Metabolism Animals Cd4-positive T-lymphocytes Cytokines Inflammation Mice Receptors, Cytokine Stat3 Transcription Factor Transcriptional Activation Transforming Growth Factors Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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