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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Himer, Leonóra Balog, Attila Szebeni, Beáta Szakál, Dorottya Nagy Sziksz, Erna Reusz, György Tulassay, Tivadar Vannay, Adám |
| Description | Author Affiliation: Himer L ( Magyar Tudományos Akadémia-Semmelweis Egyetem, Gyermekgyógyászati és Nefrológiai Kutatócsoport, Budapest. himernori@gmail.com) |
| Abstract | Th17 cells are the newly described subset of the CD4(+) T lymphocytes. Activated Th17 cells are characterized by their ability to produce IL-17A and other pro-inflammatory cytokines. IL-17A regulates immune function through its cell-surface receptor expressed on epithelial-and endothelial cells, fibroblasts and leukocytes by promoting neutrophil recruitment and releasing further pro-inflammatory mediators. Failures of the susceptible balance of the immunoregulation may lead to unchecked immune response and autoimmune diseases. The central role of Th17 cells and cytokines produced by Th17 cells were confirmed in a wide variety of human autoimmune diseases, including rheumatoid arthritis. Recently Th17 cells and its cytokines come into the focus of immunological research as potential therapeutic targets. |
| File Format | HTM / HTML |
| ISSN | 00306002 |
| e-ISSN | 17886120 |
| Journal | Orvosi Hetilap |
| Issue Number | 25 |
| Volume Number | 151 |
| Language | Hungarian |
| Publisher | Markusovszky Lajos |
| Publisher Date | 2010-06-20 |
| Publisher Place | Hungary |
| Access Restriction | Open |
| Subject Keyword | Autoimmunity Signal Transduction T-lymphocytes, Helper-inducer Receptors, Interleukin Arthritis, Rheumatoid Th2 Cells Immunology Th1 Cells Discipline Medicine Interleukin-17 |
| Alternative Title | Role of Th17 cells in rheumatoid arthritis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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