NDLI: In vitro antibacterial potential of some Vitex species against human pathogenic bacteria.

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In vitro antibacterial potential of some Vitex species against human pathogenic bacteria.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kannathasan, Krishnan Senthilkumar, Annadurai Venkatesalu, Venugopalan
Description	Country affiliation: India Author Affiliation: Kannathasan K ( Department of Botany, Annamalai University, Annamalai Nagar, Tamil Nadu, India.)
Abstract	OBJECTIVE: To study the antibacterial activity of the leaf methanol extracts of five different species of Vitex namely, Vitex altissima (V. altissima), Vitex diversifolia (V. diversifolia), Vitex negundo (V. negundo), Vitex peduncularis (V. peduncularis) and Vitex trifolia (V. trifolia). METHODS: Antibacterial assay was carried out by using disc diffusion method, determination of minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) against five strains of Gram-positive and seven strains of Gram-negative human pathogenic bacterial strains. RESULTS: The results of antibacterial activity of Vitex species showed that the extracts possessed a broad spectrum of antibacterial activity. The V. peduncularis possessed the highest activity against all the microorganisms screened. It produced a zone of inhibition ranged between (11.000 ± 0.577) and (22.670 ± 0.667) mm and the MIC values were from 62.5 to 1 000.0 µg/mL and the MBC values were from 125.0 to 2 000.0 µg/mL. CONCLUSIONS: Based on the present study, V. peduncularis is recommended for the isolation of antibacterial molecule responsible for the activity against the tested human pathogenic bacterial strains.
File Format	HTM / HTML
ISSN	19957645
e-ISSN	23524146
Journal	Asian Pacific Journal of Tropical Medicine
Issue Number	8
Volume Number	4
Language	English
Publisher	Elsevier
Publisher Date	2011-08-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline Tropical Medicine Anti-bacterial Agents Pharmacology Gram-negative Bacteria Drug Effects Gram-positive Bacteria Plant Extracts Vitex Chemistry Disk Diffusion Antimicrobial Tests Dose-response Relationship, Drug Growth & Development Pathogenicity Methanol Microbial Sensitivity Tests Plants, Medicinal
Content Type	Text
Resource Type	Article
Subject	Medicine

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