NDLI: Antileishmanial assessment of leaf extracts from Pluchea carolinensis, Pluchea odorata and Pluchea rosea.

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Antileishmanial assessment of leaf extracts from Pluchea carolinensis, Pluchea odorata and Pluchea rosea.

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Antileishmanial assessment of leaf extracts from Pluchea carolinensis, Pluchea odorata and Pluchea rosea.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	García, Marley Perera, Wilmer H. Scull, Ramón Monzote, Lianet
Description	Country affiliation: Cuba Author Affiliation: García M ( Parasitology Department, Institute of Medicine Tropical Pedro Kourí, Havana City, Cuba.)
Abstract	OBJECTIVE: To evaluate the antileishmanial activity of different extracts from three Cuban Pluchea species. METHODS: In in vitro assays the IC(50) was calculated in the promastigotes and amastigotes forms as cytotoxicity in murine macrophages. In leishmaniasis cutanea experiment, mortality, weight loss, lesion size and burden parasite were measured. RESULTS: Extracts evaluated showed inhibitive effect on growing of promastigote form; however, active extracts caused a high toxicity. Ethanol and n-hexane extracts demonstrated specific antileishmanial activity. Ethanol and n-hexane extracts from Pluchea carolinensis (P. carolinensis) caused similar inhibition against amastigote form. The intraperitoneal administration of the ethanol extract of P. carolinensis at 100 mg/kg prevented lesion development compared with control groups. CONCLUSIONS: The antileishmanial experiment suggests that ethanol extracts from P. carolinensis is the most promising. Further studies are still needed to evaluate the potential of this plant as a source of new antileishmanial agents.
File Format	HTM / HTML
ISSN	19957645
e-ISSN	23524146
Journal	Asian Pacific Journal of Tropical Medicine
Issue Number	10
Volume Number	4
Language	English
Publisher	Elsevier
Publisher Date	2011-10-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline Tropical Medicine Asteraceae Chemistry Leishmania Drug Effects Phytotherapy Plant Extracts Pharmacology Animals Disease Models, Animal Ethanol Hexanes Inhibitory Concentration 50 Mice Mice, Inbred Balb C Solvents
Content Type	Text
Resource Type	Article
Subject	Medicine

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Antileishmanial assessment of leaf extracts from Pluchea carolinensis, Pluchea odorata and Pluchea rosea.

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