NDLI: Small-cell neuroendocrine carcinoma of the prostate: are heterotransplants a better experimental model?

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Comment on “Effect of transferred NK4 gene on proliferation, migration, invasion, and apoptosis of human prostate cancer DU145 cells” by Dan Yue et al. in Asian Journal of Andrology

Effects of transferred NK4 gene on proliferation, migration, invasion and apoptosis of human prostate cancer DU145 cells

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Year: 2010 Volume: 12 Issue: 2

Year: 2010 Volume: 12 Issue: 1

Year: 2009 Volume: 11

Small-cell neuroendocrine carcinoma of the prostate: are heterotransplants a better experimental model?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lopez-Barcons, Lluis-A
Description	Country affiliation: United States Author Affiliation: Lopez-Barcons LA ( Stanley S. Scott Cancer Center, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA. lalb93@gmail.com)
Abstract	Small-cell neuroendocrine carcinoma of the prostate (SCNCP) is an uncommon type of prostate cancer. However, it is of clinical importance because it is one of the most aggressive tumors of the prostate with a very poor prognosis. There exist few artificially cultured tumor cell lines to study SCNCP. Then, another approach to that study consists in the use of fresh tumor tissue obtained from patients and its heterotransplantation into host mice. The purpose of this review is to integrate data from more than 20 years of heterotransplantation research in the study of small-cell neuroendocrine carcinoma of the prostate (SCNCP). Heterotransplantation has provided data regarding the histopathology, karyotype, DNA content, cell cycle frequency, tumor markers, androgen receptor expression, metastasis and take rate of this prostate disease. When possible, comparisons between original in situ specimens removed from patients and heterotransplanted tissue from host mice have been made. There are advantages, as well as limitations, that have been identified for SCNCP heterotransplants versus xenotransplantation of cultured cells. Overall, heterotransplanted tumors are better than conventional tumor xenografts at retaining tumor morphology, pathology, secretory activity and expression of tumor markers of the patient's original specimen. Furthermore, heterotransplanted tissue preserves the three-dimensional tumor architecture of the prostate to maintain critical stromal-epithelial cell interactions.
File Format	HTM / HTML
ISSN	1008682X
e-ISSN	17457262
DOI	10.1038/aja.2009.68
Journal	Asian Journal of Andrology
Issue Number	3
Volume Number	12
Language	English
Publisher	Wolters Kluwer - Medknow
Publisher Date	2010-05-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline Urology Carcinoma, Neuroendocrine Disease Models, Animal Prostatic Neoplasms Pathology Transplantation, Heterotopic Xenograft Model Antitumor Assays Animals Tumor Markers, Biological Metabolism Genetics Cell Cycle Dna, Neoplasm Mice Mice, Nude Receptors, Androgen
Content Type	Text
Resource Type	Article
Subject	Urology

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Small-cell neuroendocrine carcinoma of the prostate: are heterotransplants a better experimental model?